Anti-CD45RA 抗体 [F8-11-13] (ab59168)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45RA antibody [F8-11-13] (ab59168)](https://www.abcam.co.jp/ps/products/59/ab59168/Images/ab59168-73043-anti-cd45ra-antibody-f8-11-13-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45RA antibody [F8-11-13] (ab59168)")
Key features and details
- Mouse monoclonal [F8-11-13] to CD45RA
- Suitable for: IHC-P
- Reacts with: Human, Rhesus monkey
- Isotype: IgG1
製品の概要
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製品名
Anti-CD45RA antibody [F8-11-13]
CD45RA 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [F8-11-13] to CD45RA -
由来種
Mouse -
特異性
ab59168 recognises the human CD45RA cell surface antigen. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human, Rhesus monkey -
免疫原
Tissue, cells or virus corresponding to Human CD45RA. Human T lymphocytes
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ポジティブ･コントロール
- Human tonsil tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
F8-11-13 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab59168の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
| 特記事項 |
|---|
IHC-P: 1/200. Do not perform antigen retrieval.
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. -
関連疾患
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive
Multiple sclerosis -
配列類似性
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 tyrosine-protein phosphatase domains. -
ドメイン
The first PTPase domain interacts with SKAP1. -
翻訳後修飾
Heavily N- and O-glycosylated. -
細胞内局在
Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. - Information by UniProt
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参照データベース
- Entrez Gene: 5788 Human
- Omim: 151460 Human
- SwissProt: P08575 Human
- Unigene: 654514 Human
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別名
- B220 antibody
- CD45 antibody
- CD45 antigen antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45RA antibody [F8-11-13] (ab59168)Immunohistochemical analysis of formalin fixed, paraffin embedded human tonsil using ab59168 at a dilution of 1/50.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab59168 は論文での使用が確認できていません。