Anti-CD41 抗体 [MWReg30] (ab33661)
Key features and details
- Rat monoclonal [MWReg30] to CD41
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-CD41 antibody [MWReg30]
CD41 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [MWReg30] to CD41 -
由来種
Rat -
特異性
ab33661 recognizes integrin alpha IIb subunit CD41 -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
The details of the immunogen for this antibody are not available.
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特記事項
The azide free version is ab94960.Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant -
一次抗体 備考
Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo. -
ポリ/モノ
モノクローナル -
クローン名
MWReg30 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab33661の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | (1) |
1/50 - 1/100.
Use 10μl of the suggested working dilution to label 106 cells in 100μl. |
| 特記事項 |
|---|
|
Flow Cyt
1/50 - 1/100. Use 10μl of the suggested working dilution to label 106 cells in 100μl. |
ターゲット情報
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機能
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. -
組織特異性
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. -
関連疾患
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16399 Mouse
- SwissProt: Q9QUM0 Mouse
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別名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (29)
ab33661 は 29 報の論文で使用されています。
- Karreman MA et al. Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization. Cancer Res 83:1299-1314 (2023). PubMed: 36652557
- Bravo-Iñiguez CE et al. Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice. Nat Commun 14:3122 (2023). PubMed: 37264009
- Perico L et al. SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling. Sci Rep 13:11392 (2023). PubMed: 37452090
- Song H et al. The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis. Int J Biol Sci 19:3614-3627 (2023). PubMed: 37496998
- Arnold S et al. Single and Multiplex Immunohistochemistry to Detect Platelets and Neutrophils in Rat and Porcine Tissues. Methods Protoc 5:N/A (2022). PubMed: 36136817