AB15021

Anti-CD41 抗体 [HIP8]

Anti-CD41 antibody [HIP8]

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(3 Publications)

Mouse Monoclonal CD41 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human ITGA2B.

別名を表示する

CD41, GP2B, ITGAB, ITGA2B, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb

1 Images

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Flow Cyt

Lab

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Flow cytometry analysis staining CD41 in human peripheral blood cells using ab15021.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

HIP8

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Native Full Length Protein corresponding to Human ITGA2B.

P08514

特異性

Ab15021 reconizes the GPIIb-alpha (heavy chain) of CD41. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. Ab15021 [HIP8] blocks platelet aggregation and completely inhibits ADP, epinephrine, and collagen-induced platelet activation, and partially inhibits ristocetin and thrombin-induced platelet activation.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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下記製品にもご興味をお持ちいただけるかもしれません:

AB108851

Human Platelet Glycoprotein IIb + IIIa ELISA Kit

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed : 9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity).

See full target information ITGA2B

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cell 171:1368-1382.e23 PubMed29195076

2017

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Applications

Unspecified application

Species

Unspecified reactive species

Florian Gaertner,Zerkah Ahmad,Gerhild Rosenberger,Shuxia Fan,Leo Nicolai,Benjamin Busch,Gökce Yavuz,Manja Luckner,Hellen Ishikawa-Ankerhold,Roman Hennel,Alexandre Benechet,Michael Lorenz,Sue Chandraratne,Irene Schubert,Sebastian Helmer,Bianca Striednig,Konstantin Stark,Marek Janko,Ralph T Böttcher,Admar Verschoor,Catherine Leon,Christian Gachet,Thomas Gudermann,Michael Mederos Y Schnitzler,Zachary Pincus,Matteo Iannacone,Rainer Haas,Gerhard Wanner,Kirsten Lauber,Michael Sixt,Steffen Massberg

Nature protocols 5:1337-46 PubMed20595961

2010

Optimized multiparametric immunophenotyping of umbilical cord blood cells by flow cytometry.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Basford,Nico Forraz,Colin McGuckin

International journal of stem cells 3:32-45 PubMed24855539

2010

The cord blood separation league table: a comparison of the major clinical grade harvesting techniques for cord blood stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Basford,Nicolas Forraz,Saba Habibollah,Kendal Hanger,Colin McGuckin

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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Anti-CD41 抗体 [HIP8]

Anti-CD41 antibody [HIP8]

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

下記製品にもご興味をお持ちいただけるかもしれません:

Human Platelet Glycoprotein IIb + IIIa ELISA Kit

こちらの製品も推奨する理由

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (3)

Abcam product promise

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