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AB11031

Anti-CD33 抗体 [3D6]

Anti-CD33 antibody [3D6]

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(2 Publications)

Mouse Monoclonal CD33 antibody. Suitable for ELISA and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CD33.

別名を表示する

CD33, SIGLEC3, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, gp67, Siglec-3

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

3D6

アイソタイプ

IgG1

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human CD33.

P20138

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed : 10611343, PubMed : 11320212, PubMed : 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed : 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed : 10887109, PubMed : 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed : 10206955, PubMed : 10556798, PubMed : 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed : 10206955, PubMed : 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed : 15597323).
See full target information CD33
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

PLoS genetics 21:e1011600 PubMed40043053

2025

Human CD33 deficiency is associated with mild alteration of circulating white blood cell counts.

Applications

Unspecified application

Species

Unspecified reactive species

John Dominy,Jirong Bai,Christopher Koch,Maleeha Zaman Khan,Shareef Khalid,Jonathan H Chung,Madhura Panditrao,Lulu Liu,Qi Zhang,Muhammad Jahanzaib,Muhammad Rehan Mian,Muhammad Bilal Liaqat,Syed Shahzaib Raza,Riffat Sultana,Anjum Jalal,Muhammad Hamid Saeed,Shahid Abbas,Fazal Rehman Memon,Mohammad Ishaq,Kashif Saleheen,Asif Rasheed,Allan Gurtan,Danish Saleheen

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400882 PubMed39475060

2024

Outer Membrane Vesicles Derived From Fusobacterium nucleatum Trigger Periodontitis Through Host Overimmunity.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhang,Demao Zhang,Chengcheng Liu,Boyu Tang,Yujia Cui,Daimo Guo,Mengmeng Duan,Ying Tu,Huiling Zheng,Xinjie Ning,Yang Liu,Haoran Chen,Minglei Huang,Zhixing Niu,Yanfang Zhao,Xiaoheng Liu,Jing Xie
View all publications
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代替製品

Primary Antibodies

AB11032

Anti-CD33 antibody [6C5/2]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD33 antibody [6C5/2] (AB11032)

  • 3
  • 3
Primary Antibodies

AB134115

Anti-CD33 antibody [EPR4423]

20ul selling size|RabMAb|KO Validated|Recombinant

Flow Cytometry - Anti-CD33 antibody [EPR4423] (AB134115)

  • 0
  • 0
Primary Antibodies

AB215383

Anti-CD33 antibody [EPR4423] - Low endotoxin, Azide free

KO Validated|RabMAb|Recombinant

Western blot - Anti-CD33 antibody [EPR4423] - Low endotoxin, Azide free (AB215383)

  • 0
  • 0
Primary Antibodies

AB203253

Anti-CD33 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD33 antibody (AB203253)

  • 0
  • 0
Primary Antibodies

AB30371

Anti-CD33 antibody [WM53]

Recombinant|Trial Size

Flow Cytometry - Anti-CD33 antibody [WM53] (AB30371)

  • 5
  • 2

組合せ製品

Assay Kits

AB283542

Human CD33 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD33 ELISA Kit (AB283542)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB10558

Anti-CD45 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody (AB10558)

  • 4
  • 61
Primary Antibodies

AB81289

Anti-CD34 antibody [EP373Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD34 antibody [EP373Y] (AB81289)

  • 4
  • 56
Primary Antibodies

AB133357

Anti-CD11b antibody [EPR1344]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD11b antibody [EPR1344] (AB133357)

  • 4
  • 37

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