Anti-CD27 抗体 [LPFS2/1611]
Anti-CD27 antibody [LPFS2/1611]
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(2 Publications)
Mouse Monoclonal CD27 antibody. Suitable for Flow Cyt, Protein Array, ICC/IF, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CD27.
別名を表示する
CD27, TNFRSF7, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Formalin-fixed, paraffin-embedded human spleen tissue stained for CD27 using ab268144 at 2 μg/ml in immunohistochemical analysis.
- Flow Cyt
Unknown
Flow Cytometry - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Flow cytometric analysis of Ramos (Human Burkitt's lymphoma cell line) cells labeling CD27 using ab268144 at 2 μg/million cells followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Formalin-fixed, paraffin-embedded human colon tissue stained for CD27 using ab268144 at 2 μg/ml in immunohistochemical analysis.
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Immunocytochemistry/ Immunofluorescence staining of Ramos (Human Burkitt's lymphoma cell line) cells staind for CD27 using ab268144 at 2μg/ml followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for CD27 using ab268144 at 2 μg/ml in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for CD27 using ab268144 at 2 μg/ml in immunohistochemical analysis.
- Protein Array
Unknown
Protein Array - Anti-CD27 antibody [LPFS2/1611] (AB268144)
Protein Array containing more than 19,000 full-length human proteins using ab268144.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
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補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
One finds CD27 at the heart of cellular immune responses. It does not function alone; instead it typically forms part of a receptor-ligand complex with CD70 which influences T cell and B cell activities. This interaction promotes cell survival and plays a role in the activation of NF-kB and MAPK8/JNK signaling pathways which are essential for immune response regulation. These pathways ensure that the body's immune cells can efficiently respond to pathogens.
Pathways
CD27 actively integrates into the NF-kB and mTOR signaling pathways which are important for regulating immune and inflammatory responses. Through these pathways CD27 works closely with proteins like TRAF2 and TRAF3 which are adapter molecules that transmit signals from the receptor. These signaling pathways provide a framework for understanding how CD27 and associated proteins work together to control immune cell behavior facilitating coordinated immune defense mechanisms.
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ターゲットの情報
文献 (2)
Recent publications for all applications. Explore the full list and refine your search
Journal for immunotherapy of cancer 11: PubMed37072348
2023
Applications
Unspecified application
Species
Unspecified reactive species
European journal of haematology 109:513-518 PubMed35871391
2022
Applications
Unspecified application
Species
Unspecified reactive species
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