Anti-CD226 抗体 [DX11] (ab33397)
![Flow Cytometry - Anti-CD226 antibody [DX11] (ab33397)](https://www.abcam.co.jp/ps/products/33/ab33397/Images/ab33397-46687-anti-cd226-antibody-dx11-flow-cytometry.gif "Flow Cytometry - Anti-CD226 antibody [DX11] (ab33397)")
Key features and details
- Mouse monoclonal [DX11] to CD226
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-CD226 antibody [DX11]
CD226 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [DX11] to CD226 -
由来種
Mouse -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human CD226. Human cytotoxic T lymphocyte clone.
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特記事項
This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
特記事項（精製）
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant -
一次抗体 備考
This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells. -
ポリ/モノ
モノクローナル -
クローン名
DX11 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab33397の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use 10µl for 106 cells.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
Flow Cyt
Use 10µl for 106 cells. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. -
組織特異性
Expressed by peripheral blood T-lymphocytes. -
配列類似性
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 10666 Human
- Omim: 605397 Human
- SwissProt: Q15762 Human
- Unigene: 660130 Human
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別名
- adhesion glycoprotein antibody
- CD226 antibody
- CD226 antigen antibody
see all
画像
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Flow Cytometry - Anti-CD226 antibody [DX11] (ab33397)Human peripheral blood lymphocytes stained with ab33397, using 10µl of the working dilution for 106 cells in 100µl.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (7)
ab33397 は 7 報の論文で使用されています。
- Xu F et al. Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Cancer Immunol Immunother 66:1367-1375 (2017). PubMed: 28623459
- Zhu Y et al. Identification of CD112R as a novel checkpoint for human T cells. J Exp Med 213:167-76 (2016). PubMed: 26755705
- Sugai S et al. Hepatocellular carcinoma cell sensitivity to V?9Vd2 T lymphocyte-mediated killing is increased by zoledronate. Int J Oncol 48:1794-804 (2016). PubMed: 26936487
- Lozano E et al. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol 191:3673-80 (2013). Blocking ; Human . PubMed: 23980210
- Wong JL et al. IL-18-primed helper NK cells collaborate with dendritic cells to promote recruitment of effector CD8+ T cells to the tumor microenvironment. Cancer Res 73:4653-62 (2013). PubMed: 23761327
- Lozano E et al. The TIGIT/CD226 axis regulates human T cell function. J Immunol 188:3869-75 (2012). PubMed: 22427644
- Ravanat C et al. Use of tandem Biacore-mass spectrometry to identify platelet membrane targets of novel monoclonal antibodies. Anal Biochem 386:237-43 (2009). Flow Cyt ; Human . PubMed: 19135971