Anti-CD21 抗体 [1F8], prediluted (ab7290)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD21 antibody [1F8], prediluted (ab7290)](https://www.abcam.co.jp/ps/products/7/ab7290/Images/ab7290-1-anti-cd21-antibody-1f8-prediluted-immunohistochemistry-tonsil-human.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD21 antibody [1F8], prediluted (ab7290)")
Key features and details
- Mouse monoclonal [1F8] to CD21, prediluted
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
-
製品名
Anti-CD21 antibody [1F8], prediluted
CD21 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [1F8] to CD21, prediluted -
由来種
Mouse -
特異性
This antibody reacts with CD21 antigen of MW 145 kD, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human CD21. Purified receptor for the C3d fragment of the third complement component CR2, from human tonsil.
-
ポジティブ･コントロール
- Tonsil.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.3
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
1F8 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab7290の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/10 - 1/25.
|
| 特記事項 |
|---|
|
IHC-P
1/10 - 1/25. |
ターゲット情報
-
機能
Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. -
組織特異性
Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. -
関連疾患
Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
配列類似性
Belongs to the receptors of complement activation (RCA) family.
Contains 15 Sushi (CCP/SCR) domains. -
細胞内局在
Membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 1380 Human
- Omim: 120650 Human
- SwissProt: P20023 Human
- Unigene: 445757 Human
-
別名
- C3DR antibody
- CD 21 antibody
- CD21 antibody
see all
画像
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD21 antibody [1F8], prediluted (ab7290)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue labeling CD21 with ab7290.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab7290 は 1 報の論文で使用されています。
- Xu W et al. Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma. J Immunother Cancer 11:N/A (2023). PubMed: 38040418