AB37220

Anti-CD209B/DC-SIGNR1 抗体 [ER-TR9]

Name: Anti-CD209B/DC-SIGNR1 抗体 [ER-TR9] (ab37220) | Abcam
Brand: Abcam Limited
SKU: AB37220
Price: 83000 JPY
Availability: InStock
Rating: 5 (2 reviews)

Anti-CD209B/DC-SIGNR1 antibody [ER-TR9]

(2 Reviews)

(5 Publications)

Rat Monoclonal C209A antibody. Suitable for Flow Cyt, IHC-Fr, BL and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Cell preparation containing Cd209a protein.

別名を表示する

CD209, Cire, Cd209a, CD209 antigen-like protein A, Dendritic cell-specific ICAM-3-grabbing non-integrin, DC-SIGN

1 Images

Flow Cytometry - Anti-CD209B/DC-SIGNR1 antibody [ER-TR9] (AB37220)

Flow Cyt

Unknown

Flow Cytometry - Anti-CD209B/DC-SIGNR1 antibody [ER-TR9] (AB37220)

Overlay histogram showing SP0/2 cells stained with ab37220 (red line). The cells were fixed with 4% paraformaldehyde (10min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab37220, 2μg/1x10⁶ cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rat IgG (H+L) (ab98386) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rat IgM, kappa monoclonal [RTK2118] (ab35768, 2μg/1x10⁶ cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in SP0/2 cells fixed with 80% methanol (5 min) used under the same conditions.
Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

ER-TR9

アイソタイプ

IgM

キャリアフリー

交差種

Mouse

アプリケーション

IHC-Fr, Flow Cyt, BL

applications

免疫原

Cell preparation containing Cd209a protein. The exact immunogen used to generate this antibody is proprietary information.

Q91ZX1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "BL" : {"fullname" : "Blocking", "shortname":"BL"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "2 µg for 10^6 Cells", "FlowCyt-species-notes": "<a href='/products/primary-antibodies/rat-igm-kappa-monoclonal-rtk2118-isotype-control-ab35768'>ab35768</a> - Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "BL-species-checked": "guaranteed", "BL-species-dilution-info": "", "BL-species-notes": "Dilutions have to be made according to the amounts of SIGN-R1 to be inactivated." } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

Preservative: 0.02% Sodium azide Constituents: Tissue culture supernatant

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD209B also known as DC-SIGNR1 is a C-type lectin receptor with a molecular mass of about 45 kDa. This receptor is similar in structure to CD209A another member of the same gene family. CD209B is mainly expressed on macrophages and dendritic cells which are critical components of the immune system. This receptor plays a role in the immune response by recognizing and binding to specific carbohydrate structures on the surface of various pathogens.

Biological function summary

CD209B functions as part of a broader set of protein interactions involved in pathogen recognition and clearance. It acts as a pattern recognition receptor and is involved in initiating immune responses. Although not part of a large complex CD209B shares functional similarities with other receptors like CD209A mediating defensive strategies against infections through binding to glycoprotein antigens on microbes.

Pathways

The receptor participates in the immune signaling networks that oversee pathogen recognition. It is vital within the innate immune pathway where it helps to stimulate adaptive immunity. CD209B engages with proteins such as Toll-like receptors which amplify immune responses against pathogens.

CD209B has potential implications in infectious diseases and autoimmune disorders. Its ability to bind diverse pathogens makes it an important player in infections like HIV where it helps the virus gain entry into host cells. Additionally its interaction with proteins like mannose receptor suggests a role in diseases characterized by chronic inflammation. Understanding these interactions assists in developing interventions to modulate immune response in such conditions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.. On dendritic cells (DCs) it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Forms a first contact between DC and resting T cell, througth ICAM3 binding, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells.

See full target information Cd209a

追加のターゲット

Cd209b,,,

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 200:775-787 PubMed29222168

2017

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Applications

Unspecified application

Species

Unspecified reactive species

Monika Ádori,Gabriel K Pedersen,Csaba Ádori,Elina Erikson,Sharesta Khoenkhoen,Julian M Stark,Jin Huk Choi,Pia Dosenovic,Mikael C I Karlsson,Bruce Beutler,Gunilla B Karlsson Hedestam

Journal of virology 89:5904-18 PubMed25810544

2015

CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Qin,Yinyan Yin,Qinghua Yu,Lulu Huang,Xiaoqing Wang,Jian Lin,Qian Yang

Journal of immunology (Baltimore, Md. : 1950) 172:1157-62 PubMed14707091

2004

The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.

Applications

Flow Cyt, BL

Species

Mouse, Mouse

Philip R Taylor,Gordon D Brown,Jurgen Herre,David L Williams,Janet A Willment,Siamon Gordon

Journal of immunology (Baltimore, Md. : 1950) 171:6495-501 PubMed14662849

2003

The selection of marginal zone B cells differs from that of B-1a cells.

Applications

IHC-Fr

Species

Mouse

Karsten Kretschmer,Anke Jungebloud,Jana Stopkowicz,Tanja Kleinke,Reinhard Hoffmann,Siegfried Weiss

Immunology 55:23-30 PubMed3888828

1985

Marginal zone macrophages identified by a monoclonal antibody: characterization of immuno- and enzyme-histochemical properties and functional capacities.

Applications

IHC-Fr

Species

Mouse

C D Dijkstra,E Van Vliet,E A Döpp,A A van der Lelij,G Kraal

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD209B/DC-SIGNR1 抗体 [ER-TR9]

Anti-CD209B/DC-SIGNR1 antibody [ER-TR9]

Flow Cytometry - Anti-CD209B/DC-SIGNR1 antibody [ER-TR9] (AB37220)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

追加のターゲット

文献 (5)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Abcam product promise