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AB151707

Anti-CD204 抗体 [EPR7536]

Anti-CD204 antibody [EPR7536]

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(20 Publications)

Rabbit Recombinant Monoclonal CD204 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 20 publications.

別名を表示する

CD204, SCARA1, MSR1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1

4 Images
Western blot - Anti-CD204 antibody [EPR7536] (AB151707)
  • WB

Unknown

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)

All lanes:

Western blot - Anti-CD204 antibody [EPR7536] (ab151707) at 1/1000 dilution

Lane 1:

Human placenta tissue lysate at 10 µg

Lane 2:

THP1 cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Predicted band size: 50 kDa,79 kDa

false

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)
  • WB

Lab

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)

Blocking buffer : 5% NFDM/TBST
Dilution buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-CD204 antibody [EPR7536] (ab151707) at 1/1000 dilution

Lane 1:

THP-1 cell lysate at 20 µg

Lane 2:

HeLa cell lysate at 20 µg

Secondary

All lanes:

HRP goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 50 kDa

Observed band size: 75 kDa

false

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)
  • WB

Lab

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)

Blocking buffer : 5% NFDM/TBST
Dilution buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-CD204 antibody [EPR7536] (ab151707) at 1/1000 dilution

All lanes:

Mouse placenta tissue lysate at 20 µg

Secondary

All lanes:

HRP goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 50 kDa

Observed band size: 75 kDa

false

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)
  • WB

Lab

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)

Blocking buffer : 5% NFDM/TBST
Dilution buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-CD204 antibody [EPR7536] (ab151707) at 1/5000 dilution

All lanes:

Rat placenta tissue lysate at 20 µg

Secondary

All lanes:

HRP goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 50 kDa

Observed band size: 75 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-CD204 antibody [EPR7536] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR7536

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Stable for 12 months at -20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD204 also known as MSR1 or the macrophage scavenger receptor 1 is a class A scavenger receptor. It has a molecular mass of approximately 80-85 kDa. CD204 is mainly expressed on the surface of macrophages as well as some dendritic cells. This receptor plays a role in mediating the endocytosis of various polyanionic molecules such as modified low-density lipoproteins. CD204 serves as a recognition site for apoptotic cells signaling molecules and some types of bacteria.
Biological function summary

CD204 influences inflammatory responses and lipid metabolism. It does not function alone but as part of a complex involving several other molecules like pattern recognition receptors. CD204 recognizes and binds to modified lipoproteins and is significant in processes like phagocytosis and clearance of cellular debris. Its activity affects immune response modulation and can influence atherosclerosis development by its interaction with oxidized low-density lipoproteins.

Pathways

The role of CD204 extends to key cellular and immunological pathways. This receptor is involved in the Toll-like receptor signaling pathway which is important for innate immunity besides participating in the macrophage activation pathways. In these pathways CD204 interacts with other proteins including CD36 and SRA. This interaction helps coordinate inflammatory responses and the resolution of inflammation.

CD204 is associated with atherosclerosis and chronic inflammation. Its connection with these conditions arises from its role in lipid uptake and immune cell regulation within the vascular system. In the context of atherosclerosis CD204's interaction with Apolipoprotein E (ApoE) influences the formation of foam cells which are significant in the disease's progression. Similarly in chronic inflammation CD204 modulates macrophage behavior impacting the inflammatory environment and potentially affecting the disease outcome.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed : 2251254). Isoform III does not internalize acetylated LDL (PubMed : 9548586).
See full target information MSR1
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文献 (20)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113405 PubMed40978144

2025

Histone demethylase LSD1 regulates lipid homeostasis during infection.

Applications

Unspecified application

Species

Unspecified reactive species

Gaurav Kumar Lohia,Awantika Shah,Kithiganahalli Narayanaswamy Balaji

Food & nutrition research 69: PubMed40475061

2025

Protective effect of water extract and its main compound, Cycloalliin, on foam cell formation in THP-1-derived macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Ha-Rin Moon,Jung-Mi Yun

Scientific reports 15:6941 PubMed40011664

2025

PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Feng Cui,Xiao Cui Chen,Tuoluonayi Mijiti,Abidan Abudurusuli,Li Hui Deng,Xiang Ma,Bangdang Chen

Journal of inflammation research 17:2873-2887 PubMed38741612

2024

Transcriptomic Insights into Different Stimulation Intensity of Electroacupuncture in Treating COPD in Rat Models.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Liu,Zili Tang,Qian Zeng,Wenchuan Qi,Ziyang Zhou,Daohong Chen,Dingjun Cai,Ying Chen,Shiqi Sun,Siyao Gong,Bin He,Shuguang Yu,Ling Zhao

Molecular medicine (Cambridge, Mass.) 30:38 PubMed38493291

2024

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Weijie Liang,Ruibin Wei,Xingxing Zhu,Jinliang Li,Aiwen Lin,Jun Chen,Wen Wu,Qiang Jie

Nature communications 15:1663 PubMed38396109

2024

A co-assembly platform engaging macrophage scavenger receptor A for lysosome-targeting protein degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Wang,Xingyue Yang,Ruixin Yuan,Ao Shen,Pushu Wang,Haoting Li,Jun Zhang,Chao Tian,Zhujun Jiang,Wenzhe Li,Suwei Dong

Cells 12: PubMed38132146

2023

Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Elizeth Lopes,Gisela Machado-Oliveira,Catarina Guerreiro Simões,Inês S Ferreira,Cristiano Ramos,José Ramalho,Maria I L Soares,Teresa M V D Pinho E Melo,Rosa Puertollano,André R A Marques,Otília V Vieira

Cell death & disease 14:542 PubMed37607939

2023

Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6.

Applications

Unspecified application

Species

Unspecified reactive species

Qiming Deng,Hongxuan Li,Xiaolin Yue,Chenghu Guo,Yuanyuan Sun,Chang Ma,Jiangang Gao,Yue Wu,Bin Du,Jianmin Yang,Cheng Zhang,Wencheng Zhang

EBioMedicine 90:104480 PubMed36863256

2023

A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.

Applications

Unspecified application

Species

Unspecified reactive species

Yawei Wang,Binlin Tang,Huijuan Li,Jiancheng Zheng,Can Zhang,Zeyu Yang,Xu Tan,Peng Luo,Le Ma,Yang Wang,Lei Long,Zelin Chen,Zhenliang Xiao,Lijie Ma,Jing Zhou,Yu Wang,Chunmeng Shi

International journal of molecular sciences 24: PubMed36768908

2023

Activation of the RARα Attenuated CSF Hypersecretion to Inhibit Hydrocephalus Development via Regulating the MAFB/MSR1 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hanhai Zeng,Kaibo Yu,Junyou Wang,Jingya Ye,Huaijun Chen,Chaoran Xu,Ting Chen,Feng Yan,Gao Chen,Chi Gu
View all publications
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