Anti-CD20 抗体 (ab27093)
Key features and details
- Rabbit polyclonal to CD20
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-CD20 antibody
CD20 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CD20 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human CD20 aa 250 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: P11836 -
特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab27093 is an affinity purified IgG. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab27093の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
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IHC-P |
1/300. Antigen retrieval is not essential but may optimise staining.
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特記事項 |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 33 kDa. |
IHC-P
1/300. Antigen retrieval is not essential but may optimise staining. |
ターゲット情報
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機能
This protein may be involved in the regulation of B-cell activation and proliferation. -
組織特異性
Expressed on B-cells. -
関連疾患
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
配列類似性
Belongs to the MS4A family. -
翻訳後修飾
Phosphorylated. Might be functionally regulated by protein kinase(s). -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 931 Human
- Omim: 112210 Human
- SwissProt: P11836 Human
- Unigene: 712553 Human
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別名
- APY antibody
- ATOPY antibody
- B lymphocyte antigen CD20 antibody
see all
画像
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Formalin fixed, paraffin embedded human tonsil tissue slide stained with anti CD20 antibody (ab27093).
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Anti-CD20 antibody (ab27093) at 1/25 dilution + Raji cell lysate
Predicted band size: 33 kDa
Observed band size: 35 kDa why is the actual band size different from the predicted?
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab27093 は 10 報の論文で使用されています。
- Kosenda K et al. Histological Characteristics of Conjunctiva-Associated Lymphoid Tissue in Young and Adult Holstein Cattle. Animals (Basel) 13:N/A (2023). PubMed: 38003099
- Sirivisoot S et al. Evaluation of 41 single nucleotide polymorphisms in canine diffuse large B-cell lymphomas using MassARRAY. Sci Rep 12:5120 (2022). PubMed: 35332215
- Wei ZW et al. Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour. EBioMedicine 57:102850 (2020). PubMed: 32574962
- Webb GM et al. The human IL-15 superagonist ALT-803 directs SIV-specific CD8+T cells into B-cell follicles. Blood Adv 2:76-84 (2018). IHC-P ; Rhesus monkey . PubMed: 29365313
- Stahl EC et al. Evaluation of the host immune response to decellularized lung scaffolds derived from a-Gal knockout pigs in a non-human primate model. Biomaterials 187:93-104 (2018). PubMed: 30312852
- Miles B et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog 12:e1005924 (2016). IHC (PFA fixed) ; Rhesus monkey . PubMed: 27716848
- Miles B et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun 6:8608 (2015). PubMed: 26482032
- Bojarczuk K et al. B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies. Leukemia N/A:N/A (2014). Human . PubMed: 24492323
- Connick E et al. Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL. J Immunol 193:5613-25 (2014). PubMed: 25362178
- Moll NM et al. Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis. Arch Neurol 66:44-53 (2009). IHC-Fr ; Human . PubMed: 19139298