AB156708

Anti-CD1c 抗体 [OTI2F4]

Name: Anti-CD1c 抗体 [OTI2F4] (ab156708) | Abcam
Brand: Abcam Limited
SKU: AB156708
Price: 61000 JPY
Availability: InStock
Rating: 5 (4 reviews)

Anti-CD1c antibody [OTI2F4]

(4 Reviews)

(14 Publications)

Anti-CD1c antibody [OTI2F4] (ab156708) is a mouse monoclonal antibody detecting CD1c in Western Blot, IHC-P. Suitable for Human.

- Over 10 publications

別名を表示する

CD1c, T-cell surface glycoprotein CD1c, CD1C

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

IHC-P

AbReview40945****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

ab156708 staining MAFA in Cynomolgus monkey lymph node sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 10% donkey serum for 20 minutes at romm temperature; antigen retrieval was by heat mediation. Samples were incubated with primary antibody (1/50) for 30 minutes at room temperature. A Biotin-conjugated Donkey anti-mouse IgG polyclonal (1/2000) was used as the secondary antibody.

This image is courtesy of an Abreview submitted by Jing Ma

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-CD1C mouse monoclonal antibody(ab156708)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-CD1C mouse monoclonal antibody. (ab156708)

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

OTI2F4

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human CD1C.

P29017

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }

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製品の詳細

What is this antibody validated in?
Anti-CD1c antibody [OTI2F4] (ab156708) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples.

What is the molecular weight of CD1c?
Anti-CD1c [OTI2F4] (ab156708) specifically detects a band for CD1c (UniProt: P29017) at a molecular weight of 38kDa.

Trusted by the scientific community
Anti-CD1c [OTI2F4] (ab156708) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

Purified from TCS

バッファー組成

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD1c also known as CD1c molecule or R7 is a transmembrane glycoprotein with a molecular weight of approximately 43 kDa. It belongs to the CD1 family of glycoproteins which share structural similarity to major histocompatibility complex (MHC) proteins. CD1c presents lipid and glycolipid antigens to T cells. It is expressed on professional antigen-presenting cells (APCs) like dendritic cells B cells and some monocytes. This expression allows CD1c to function in the immune response by presenting specialized antigens to T cells.

Biological function summary

The function of CD1c involves the presentation of lipid antigens which plays a role in immune recognition. CD1c is a part of a complex that includes Β2-microglobulin which stabilizes its structure for antigen presentation. CD1c contributes to the immune surveillance by enabling the recognition of microbial lipid antigens as well as self-lipids by specific T cell subsets. This function supports the body's immune defense by identifying and reacting to potential pathogenic lipids.

Pathways

CD1c is involved in immune response pathways that center around antigen presentation. It interacts with other proteins like CD1a CD1b and CD1d expanding the range of antigens that T cells can recognize. CD1c participates in the lipid antigen presentation pathway influencing both innate and adaptive immunity. The presentation of lipid antigens by CD1c to T cells can trigger signaling pathways that affect both immune activation and resolution.

CD1c is implicated in autoimmune diseases and infections. Its role in antigen presentation makes it a potential factor in autoimmune conditions where immune recognition errors might occur. Additionally CD1c may relate to infectious diseases where mycobacteria or other pathogens present unique lipid antigens. Through its interaction with T cell receptors CD1c can impact how well immune responses are mounted against these challenges making it a notable target for therapeutic development and research.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

See full target information CD1C

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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

European journal of immunology 54:e2350891 PubMed38509863

2024

cDC2 plasticity and acquisition of a DC3-like phenotype mediated by IL-6 and PGE2 in a patient-derived colorectal cancer organoids model.

Applications

Unspecified application

Species

Unspecified reactive species

Beatriz Subtil,Iris A E van der Hoorn,Jorge Cuenca-Escalona,Anouk M D Becker,Mar Alvarez-Begue,Kirti K Iyer,Jorien Janssen,Tom van Oorschot,Dennis Poel,Mark A J Gorris,Koen van den Dries,Alessandra Cambi,Daniele V F Tauriello,I Jolanda M de Vries

PeerJ 11:e16618 PubMed38099311

2023

Identifying as a potential biomarker by the comprehensive exploration of tumor mutational burden and immune infiltration in diffuse large B cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyu Xiang,Li-Min Gao,Yuehua Zhang,Qiqi Zhu,Sha Zhao,Weiping Liu,Yunxia Ye,Yuan Tang,Wenyan Zhang

Frontiers in immunology 14:1216352 PubMed37539048

2023

Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Lang,Corinna Krump,Anastasia Meshcheryakova,Carmen Tam-Amersdorfer,Elke Schwarzenberger,Christina Passegger,Sally Connolly,Diana Mechtcheriakova,Herbert Strobl

EBioMedicine 86:104371 PubMed36434949

2022

Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wen,Shuogui Fang,Yi Hu,Mian Xi,Zelin Weng,Chuqing Pan,Kongjia Luo,Yihong Ling,Renchun Lai,Xiuying Xie,Xiaodan Lin,Ting Lin,Jiyang Chen,Qianwen Liu,Jianhua Fu,Hong Yang

Frontiers in immunology 13:874255 PubMed35663986

2022

Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.

Applications

Unspecified application

Species

Unspecified reactive species

Srinand Sundaram,Eun Na Kim,Georgina M Jones,Shamilene Sivagnanam,Monika Tripathi,Ahmad Miremadi,Massimiliano Di Pietro,Lisa M Coussens,Rebecca C Fitzgerald,Young Hwan Chang,Lizhe Zhuang

Cancer cell 40:424-437.e5 PubMed35303421

2022

Immune phenotypic linkage between colorectal cancer and liver metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yedan Liu,Qiming Zhang,Baocai Xing,Nan Luo,Ranran Gao,Kezhuo Yu,Xueda Hu,Zhaode Bu,Jirun Peng,Xianwen Ren,Zemin Zhang

Cancer cell 39:1594-1609.e12 PubMed34767762

2021

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew M Leader,John A Grout,Barbara B Maier,Barzin Y Nabet,Matthew D Park,Alexandra Tabachnikova,Christie Chang,Laura Walker,Alona Lansky,Jessica Le Berichel,Leanna Troncoso,Nausicaa Malissen,Melanie Davila,Jerome C Martin,Giuliana Magri,Kevin Tuballes,Zhen Zhao,Francesca Petralia,Robert Samstein,Natalie Roy D'Amore,Gavin Thurston,Alice O Kamphorst,Andrea Wolf,Raja Flores,Pei Wang,Sören Müller,Ira Mellman,Mary Beth Beasley,Hélène Salmon,Adeeb H Rahman,Thomas U Marron,Ephraim Kenigsberg,Miriam Merad

Cell 182:886-900.e17 PubMed32783918

2020

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Molgora,Ekaterina Esaulova,William Vermi,Jinchao Hou,Yun Chen,Jingqin Luo,Simone Brioschi,Mattia Bugatti,Andrea Salvatore Omodei,Biancamaria Ricci,Catrina Fronick,Santosh K Panda,Yoshiko Takeuchi,Matthew M Gubin,Roberta Faccio,Marina Cella,Susan Gilfillan,Emil R Unanue,Maxim N Artyomov,Robert D Schreiber,Marco Colonna

Translational oncology 13:100790 PubMed32428851

2020

IGF1R Axis Inhibition Restores Dendritic Cell Antitumor Response in Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lina Somri-Gannam,Shilhav Meisel-Sharon,Shay Hantisteanu,Gabriel Groisman,Ofer Limonad,Mordechai Hallak,Ilan Bruchim

Cell reports 30:1027-1038.e4 PubMed31995747

2020

Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination.

Applications

Unspecified application

Species

Unspecified reactive species

Jasper J P van Beek,Georgina Flórez-Grau,Mark A J Gorris,Till S M Mathan,Gerty Schreibelt,Kalijn F Bol,Johannes Textor,I Jolanda M de Vries

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD1c 抗体 [OTI2F4]

Anti-CD1c antibody [OTI2F4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (14)

Abcam product promise