JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB18216

Anti-CD1c 抗体 [M241]

Anti-CD1c antibody [M241]

Be the first to review this product! Submit a review

|

(3 Publications)

Mouse Monoclonal CD1C antibody. Suitable for IHC, IP, RID and reacts with Human samples. Cited in 3 publications.

別名を表示する

CD1c, T-cell surface glycoprotein CD1c, CD1C

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

M241

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

IP, IHC, RID

applications

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "RID" : {"fullname" : "Radial Immunodiffusion", "shortname":"RID"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHC-species-checked": "guaranteed", "IHC-species-dilution-info": "", "IHC-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "RID-species-checked": "guaranteed", "RID-species-dilution-info": "", "RID-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
バッファー組成
Preservative: 0.02% Sodium azide Constituents: 99.98% PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD1c also known as CD1c molecule or R7 is a transmembrane glycoprotein with a molecular weight of approximately 43 kDa. It belongs to the CD1 family of glycoproteins which share structural similarity to major histocompatibility complex (MHC) proteins. CD1c presents lipid and glycolipid antigens to T cells. It is expressed on professional antigen-presenting cells (APCs) like dendritic cells B cells and some monocytes. This expression allows CD1c to function in the immune response by presenting specialized antigens to T cells.
Biological function summary

The function of CD1c involves the presentation of lipid antigens which plays a role in immune recognition. CD1c is a part of a complex that includes β2-microglobulin which stabilizes its structure for antigen presentation. CD1c contributes to the immune surveillance by enabling the recognition of microbial lipid antigens as well as self-lipids by specific T cell subsets. This function supports the body's immune defense by identifying and reacting to potential pathogenic lipids.

Pathways

CD1c is involved in immune response pathways that center around antigen presentation. It interacts with other proteins like CD1a CD1b and CD1d expanding the range of antigens that T cells can recognize. CD1c participates in the lipid antigen presentation pathway influencing both innate and adaptive immunity. The presentation of lipid antigens by CD1c to T cells can trigger signaling pathways that affect both immune activation and resolution.

CD1c is implicated in autoimmune diseases and infections. Its role in antigen presentation makes it a potential factor in autoimmune conditions where immune recognition errors might occur. Additionally CD1c may relate to infectious diseases where mycobacteria or other pathogens present unique lipid antigens. Through its interaction with T cell receptors CD1c can impact how well immune responses are mounted against these challenges making it a notable target for therapeutic development and research.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
See full target information CD1C
style
left-column

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular gastroenterology and hepatology 5:31-49 PubMed29188232

2017

Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System.

Applications

Unspecified application

Species

Unspecified reactive species

Emilie Duchalais,Christophe Guilluy,Steven Nedellec,Melissa Touvron,Anne Bessard,Yann Touchefeu,Céline Bossard,Hélène Boudin,Guy Louarn,Michel Neunlist,Laurianne Van Landeghem

Human immunology 25:181-93 PubMed2670851

1989

Characterization of B cells in severe combined immunodeficiency disease.

Applications

Unspecified application

Species

Unspecified reactive species

T N Small,C Keever,N Collins,B Dupont,R J O'Reilly,N Flomenberg

European journal of immunology 12:676-81 PubMed6754387

1982

A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.

Applications

Unspecified application

Species

Unspecified reactive species

R W Knowles,W F Bodmer
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB190305

Anti-CD1c antibody [L161]

KO Validated

Flow Cytometry - Anti-CD1c antibody [L161] (AB190305)

  • 0
  • 0
Primary Antibodies

AB167419

Anti-CD1c antibody [EPR9638]

RabMAb|Recombinant

Western blot - Anti-CD1c antibody [EPR9638] (AB167419)

  • 0
  • 0
Primary Antibodies

AB156708

Anti-CD1c antibody [OTI2F4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [OTI2F4] (AB156708)

  • 5
  • 4

Complementary Products

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 18
Primary Antibodies

AB223188

Anti-CLEC9A antibody [EPR22324]

RabMAb|Recombinant

Flow Cytometry - Anti-CLEC9A antibody [EPR22324] (AB223188)

  • 0
  • 0
Primary Antibodies

AB955

Anti-CD68 antibody [KP1]

Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [KP1] (AB955)

  • 4
  • 48
Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

  • 5
  • 18

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com