AB212391

Anti-CD15 抗体 [Leu-M1] - BSA and Azide free

Name: Anti-CD15 抗体 [Leu-M1] - BSA and Azide free (ab212391) | Abcam
Brand: Abcam Limited
SKU: AB212391
Price: 129000 JPY
Availability: InStock

Anti-CD15 antibody [Leu-M1] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal CD15 antibody. Carrier free. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD15 protein.

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [Leu-M1] - BSA and Azide free (AB212391)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [Leu-M1] - BSA and Azide free (AB212391)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Hodgkin's lymphoma tissue section labeling FUT4 with ab212391 at 1μg/mL.

Flow Cytometry - Anti-CD15 antibody [Leu-M1] - BSA and Azide free (AB212391)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD15 antibody [Leu-M1] - BSA and Azide free (AB212391)

Flow cytometric analysis of Human monocytes labeling FUT4 with ab212391.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

Leu-M1

アイソタイプ

IgM

軽鎖のタイプ

kappa

キャリアフリー

Yes

交差種

Human

アプリケーション

Flow Cyt, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5-1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>for 30 minutes at room temperature.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製に関する特記事項

ab212391 is purified from Bioreactor Concentrate.

バッファー組成

pH: 7.2 - 7.4 Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD15 also known as Lewis x or 3-fucosyl-N-acetyllactosamine is a carbohydrate antigen with a molecular mass typically not individually defined due to its nature as a glycan. CD15 is expressed on the surface of many human cells including neutrophils and various epithelial cells. It is commonly associated with granulocytes and is used as a cell surface marker. The presence of CD15 can be identified using CD15 antibodies through techniques such as CD15 flow cytometry and CD15 APC labeling.

Biological function summary

CD15 is important in cell-cell interaction mechanisms. It plays a role in mediating adhesion processes particularly in immune responses where it aids neutrophils in adhering to vascular endothelium and transmigrating to sites of infection or inflammation. As a glycoconjugate CD15 forms part of a larger glycoprotein complex on the cell surface interacting with other proteins to facilitate cellular responses and movement.

Pathways

CD15's function as an adhesion molecule ties into key cellular processes such as the selectin pathway. In this pathway it interacts with proteins like E-selectin and L-selectin contributing to leukocyte rolling and extravasation during the immune response. Additionally CD15 is implicated in the signaling pathways that mediate inflammatory responses where its role in neutrophil dynamics is important.

CD15 has notable implications in Hodgkin's lymphoma and certain myeloid leukemias. It is frequently used as a diagnostic marker in these conditions where its overexpression or abnormal expression patterns may signify disease presence or progression. CD15's interaction with other proteins such as CD30 in Hodgkin's lymphoma highlights its utility in understanding the pathological mechanisms and potential therapeutic targets of these disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information CD15

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107648 PubMed37670782

2023

Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Aakash Mahant Mahant,Fatima Estrada Trejo,Jennifer T Aguilan,Simone Sidoli,Sallie R Permar,Betsy C Herold

View all publications

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