AB203220

Anti-CD134 / OX40L receptor 抗体

Name: Anti-CD134 / OX40L receptor 抗体 (ab203220) | Abcam
Brand: Abcam Limited
SKU: AB203220
Price: 75000 JPY
Availability: InStock
Rating: 5 (3 reviews)

Anti-CD134 / OX40L receptor antibody

(3 Reviews)

(5 Publications)

Rabbit Polyclonal CD134 / OX40L receptor antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (AB203220)

IHC-P

AbReview54344****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (AB203220)

Formaldehyde-fixed, paraffin-embedded mouse spleen tissue stained for CD134 / OX40L receptor using ab203220 at 1/200 dilution in immunohistochemical analysis.

This image is courtesy of an anonymous Abreview.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (AB203220)

Formaldehyde-fixed, paraffin-embedded mouse spleen tissue stained for CD134 / OX40L receptor using ab203220 at 1/200 dilution in immunohistochemical analysis.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat, Human

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human TNFRSF4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P43489

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "1/50-1/200 when using fluorescent detection methods." }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.

Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

See full target information TNFRSF4

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 13: PubMed38930150

2024

Prognostic Role of OX40, LAG-3, TIM-3 and PD-L1 Expression in Bone and Soft Tissue Sarcomas.

Applications

Unspecified application

Species

Unspecified reactive species

Bediz Kurt İnci,Elif Acar,Fatih Gürler,Ayşegül İlhan,Fatih Yıldız,Fisun Ardıç,Berna Öksüzoğlu,Nuriye Özdemir,Ahmet Özet,Güldal Esendağlı,Ozan Yazıcı

Oncoimmunology 10:1947665 PubMed34290908

2021

An immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC).

Applications

Unspecified application

Species

Unspecified reactive species

Haoyue Guo,Binglei Li,Li Diao,Hao Wang,Peixin Chen,Minlin Jiang,Lishu Zhao,Yayi He,Caicun Zhou

Neuropathology : official journal of the Japanese Society of Neuropathology : PubMed29582466

2018

Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroaki Miyahara,Kouki Miyakawa,Haruto Nishida,Shinji Yano,Tomoko Sonoda,So-Ichi Suenobu,Tatsuro Izumi,Tsutomu Daa,Kenji Ihara

Cancer prevention research (Philadelphia, Pa.) 10:684-693 PubMed29018057

2017

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Tongxin Xie,Bingbing Wang,William N William,John V Heymach,Adel K El-Naggar,Jeffrey N Myers,Carlos Caulin

International journal of molecular medicine 39:144-152 PubMed27878248

2016

Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation.

Applications

Species

Rat

Tao Liu,Yue Zhang,Zhongyang Shen,Xunfeng Zou,Xiaobo Chen,Li Chen,Yuliang Wang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD134 / OX40L receptor 抗体

Anti-CD134 / OX40L receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (AB203220)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody (AB203220)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (5)

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Abcam product promise