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Anti-CD130 (gp130) 抗体 [B-T2] (ab11462)

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Key features and details

  • Mouse monoclonal [B-T2] to CD130 (gp130)
  • Suitable for: ELISA, Flow Cyt
  • Reacts with: Human
  • Isotype: IgG1

製品の概要

  • 製品名

    Anti-CD130 (gp130) antibody [B-T2]
    CD130 (gp130) 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [B-T2] to CD130 (gp130)

  • 由来種

    Mouse

  • アプリケーション

    適用あり: ELISA, Flow Cytmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Natural soluble gp130 receptor (Human).

  • 特記事項

    Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab11462の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
ELISA
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Use 0.2µg for 106 cells. Use 10µl of the suggested working dilution to label 106 cells in 100µl.
特記事項
ELISA
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Use 0.2µg for 106 cells. Use 10µl of the suggested working dilution to label 106 cells in 100µl.

ターゲット情報

  • 機能

    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

  • 組織特異性

    Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

  • 配列類似性

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

  • ドメイン

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

  • 翻訳後修飾

    Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.

  • 細胞内局在

    Secreted and Cell membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • CD130 antibody
      • CD130 antigen antibody
      • CDw130 antibody
      • gp130 antibody
      • GP130 RAPS antibody
      • IL 6R beta antibody
      • IL-6 receptor subunit beta antibody
      • IL-6R subunit beta antibody
      • IL-6R-beta antibody
      • IL-6RB antibody
      • IL6 ST antibody
      • IL6RB_HUMAN antibody
      • IL6ST antibody
      • Interleukin 6 receptor subunit beta antibody
      • Interleukin receptor beta chain antibody
      • Interleukin-6 receptor subunit beta antibody
      • Interleukin-6 signal transducer antibody
      • Membrane glycoprotein 130 antibody
      • Membrane glycoprotein gp130 antibody
      • Oncostatin M receptor antibody
      • Oncostatin M receptor alpha subunit antibody
      • Oncostatin-M receptor subunit alpha antibody
      see all

    参考文献 (2)

    ab11462 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab11462 は 2 報の論文で使用されています。

    • Składanowska K  et al. Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep 41:111490 (2022). PubMed: 36261006
    • Sommer J  et al. Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling. J Biol Chem 287:13743-51 (2012). PubMed: 22523320

    レビューと Q&A

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