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AB219799

Anti-CD11c 抗体 [EPR21826]

Anti-CD11c antibody [EPR21826]

4

(7 Reviews)

|

(12 Publications)

Anti-CD11c antibody [EPR21826] (ab219799) is a rabbit monoclonal antibody detecting CD11c in Flow Cytometry, IHC-P. Suitable for Mouse.

- Biophysical QC for unrivalled batch-batch consistency
- Over 10 publications

別名を表示する

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EPR21826] (AB219799)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EPR21826] (AB219799)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue labeling CD11c with ab219799 at 1/100 dilution, followed by ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101). Positive staining on dendritic cells of mouse spleen (PMID : 20194631, PMID : 15795237) is observed. Counterstained with hematoxylin.
Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101).

Flow Cytometry - Anti-CD11c antibody [EPR21826] (AB219799)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD11c antibody [EPR21826] (AB219799)

Flow cytometric analysis of mouse primary splenocytes labeling CD11c with ab219799 at a 1/50 dilution.

Cells were stained with BV421 conjugated CD11b and rabbit IgG (Left panel) or CD11c (Right panel).

Goat anti rabbit IgG (Alexa Fluor® 488, ab150077), at 1/2000 dilution was used as the secondary antibody.

Gated on viable cells.

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-CD11c antibody [EPR21826] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR21826

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse

アプリケーション

IHC-P, Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p>During IHC-P detection, we recommend using the manual two-step method and selecting polymer-based secondary antibodies to enhance signal intensity.</p>", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/50", "FlowCyt-species-notes": "<p></p>" } } }
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製品の詳細

What is this antibody validated in?
Anti-CD11c antibody [EPR21826] (ab219799) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Mouse samples.

Trusted by the scientific community
Anti-CD11c [EPR21826] (ab219799) was first used in a scientific publication in 2018 and has been cited over 10 times in peer-reviewed journals.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Other related products
We have a range of other formats of antibody clone [EPR21826] also available for your convenience: ab219799, Carrier free - ab240558

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).
See full target information Itgax
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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1241949 PubMed37849752

2023

Targeting the pericyte antigen DLK1 with an alpha type-1 polarized dendritic cell vaccine results in tumor vascular modulation and protection against colon cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda L McCormick,Trevor S Anderson,Elizabeth A Daugherity,Izuchukwu F Okpalanwaka,Savanna L Smith,Duke Appiah,Devin B Lowe

Frontiers in immunology 14:1162799 PubMed37261358

2023

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Shannon N Loftus,Jianhua Liu,Celine C Berthier,Johann E Gudjonsson,Mehrnaz Gharaee-Kermani,Lam C Tsoi,J Michelle Kahlenberg

Experimental dermatology 32:878-888 PubMed36928929

2023

Topical application of imatinib mesylate ameliorated psoriasis-like skin lesions in imiquimod-induced murine model via angiogenesis inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuma Hayakawa,Tatsuo Maeda,Chizu Egusa,Yukari Okubo,Kazutoshi Harada

Frontiers in immunology 14:1133177 PubMed36993983

2023

Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA.

Applications

Unspecified application

Species

Unspecified reactive species

Fabrizio Celesti,Andrea Gatta,Mariam Shallak,Anna Maria Chiaravalli,Michele Cerati,Fausto Sessa,Roberto S Accolla,Greta Forlani

Molecular and cellular biochemistry 478:1611-1620 PubMed36441354

2022

(-)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohui Yang,Junling Yang,Xiaoxia Gu,Yuhua Tao,Hongjuan Ji,Xian Miao,Shuijie Shen,Haiyang Zang

Cell proliferation 55:e13328 PubMed36106559

2022

Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Tu,Yi Li,Jiali Zhu,Long Guo,Chenchen Liu,Lu Liu,Yuan Yuan,Yun Zou,Feng Chen,Liangfang Yao,Jinbao Li

Theranostics 12:4606-4628 PubMed35832091

2022

Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Ren-Qi Yao,Zhi-Xuan Li,Li-Xue Wang,Yu-Xuan Li,Li-Yu Zheng,Ning Dong,Yao Wu,Zhao-Fan Xia,Timothy R Billiar,Chao Ren,Yong-Ming Yao

Computational intelligence and neuroscience 2022:5173836 PubMed35619768

2022

Zizhu Ointment Accelerates Wound-Healing of Diabetic Ulcers through Promoting M2 Macrophage Polarization via Downregulating the Notch4 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Renyan Huang,Xiaoming Hu,Wenhui Li,Lixiang Wang,Weijing Fan,Qiang Han,Fang Guo,Guobin Liu

Obesity (Silver Spring, Md.) 30:153-164 PubMed34825496

2021

Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Zahraa Abdul Sater,Cheryl Cero,Anne E Pierce,Hannah J Lea,Houssein Abdul Sater,Kenneth Y Zhu,Naili Liu,Yinyan Ma,Oksana Gavrilova,Aaron M Cypess

Cell reports 36:109422 PubMed34289373

2021

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Anthony B Rodriguez,J David Peske,Amber N Woods,Katie M Leick,Ileana S Mauldin,Max O Meneveau,Samuel J Young,Robin S Lindsay,Marit M Melssen,Salwador Cyranowski,Geoffrey Parriott,Mark R Conaway,Yang-Xin Fu,Craig L Slingluff,Victor H Engelhard
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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