Anti-CD11b 抗体 [ICRF44] (ab34216)
Key features and details
- Mouse monoclonal [ICRF44] to CD11b
- Suitable for: IP, WB, Flow Cyt
- Reacts with: Human, Pig, Chimpanzee, Cynomolgus monkey, Rhesus monkey
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-CD11b antibody [ICRF44]
CD11b 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [ICRF44] to CD11b -
由来種
Mouse -
アプリケーション
適用あり: IP, WB, Flow Cytmore details -
種交差性
交差種: Human, Pig, Chimpanzee, Cynomolgus monkey, Rhesus monkey -
免疫原
Tissue, cells or virus corresponding to Human CD11b.
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ポジティブ・コントロール
- Human tonsil.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.87% Sodium chloride, 0.142% Monobasic dihydrogen sodium phosphate -
Concentration information loading...
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精製度
SDS-PAGE -
ポリ/モノ
モノクローナル -
クローン名
ICRF44 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
- PE/Cy7® Anti-CD11b antibody [ICRF44], prediluted (ab135929)
- FITC Anti-CD11b antibody [ICRF44] (ab176541)
- Alexa Fluor® 488 Anti-CD11b antibody [ICRF44], prediluted (ab187597)
- APC/Cy7® Anti-CD11b antibody [ICRF44] (ab197129)
- APC Anti-CD11b antibody [ICRF44] (ab218639)
- Biotin Anti-CD11b antibody [ICRF44] (ab239235)
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab34216の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IP |
Use at an assay dependent concentration.
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IF |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
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特記事項 |
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IP
Use at an assay dependent concentration. |
IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
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機能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
組織特異性
Predominantly expressed in monocytes and granulocytes. -
関連疾患
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 454069 Chimpanzee
- Entrez Gene: 101866035 Cynomolgus monkey
- Entrez Gene: 3684 Human
- Entrez Gene: 714832 Rhesus monkey
- Omim: 120980 Human
- SwissProt: P11215 Human
- Unigene: 172631 Human
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別名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (11)
ab34216 は 11 報の論文で使用されています。
- Yoshida S et al. Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2. Arthritis Rheumatol 75:950-960 (2023). PubMed: 36530127
- Premadasa LS et al. Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection. JCI Insight 8:N/A (2023). PubMed: 37036007
- Buhe H et al. IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma. Acta Pharmacol Sin N/A:N/A (2022). PubMed: 36517670
- Kim YK et al. A Pilot Study To Establish an Ovalbumin-induced Atopic Dermatitis Minipig Model. J Vet Res 65:307-313 (2021). PubMed: 34917843
- Huang Y et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2-mediated osteoclastogenesis induced by RANKL/M-CSF. Exp Ther Med 20:736-747 (2020). PubMed: 32742319