JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB231557

Anti-CCL28/MEC 抗体

Anti-CCL28/MEC antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal CCL28/MEC antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Ccl28.

別名を表示する

SCYA28, CCL28, C-C motif chemokine 28, Mucosae-associated epithelial chemokine, Protein CCK1, Small-inducible cytokine A28, MEC

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL28/MEC antibody (AB231557)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL28/MEC antibody (AB231557)

Formalin-fixed, paraffin-embedded mouse testis tissue stained for CCL28/MEC using ab231557 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-CCL28/MEC antibody (AB231557)
  • WB

Supplier Data

Western blot - Anti-CCL28/MEC antibody (AB231557)

All lanes:

Western blot - Anti-CCL28/MEC antibody (ab231557) at 2 µg/mL

All lanes:

Mouse spleen lysate

Predicted band size: 14 kDa

false

Western blot - Anti-CCL28/MEC antibody (AB231557)
  • WB

Supplier Data

Western blot - Anti-CCL28/MEC antibody (AB231557)

All lanes:

Western blot - Anti-CCL28/MEC antibody (ab231557) at 2 µg/mL

All lanes:

Recombinant mouse CCL28/MEC protein

Predicted band size: 14 kDa,45 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Mouse Ccl28.

Q9JIL2

style
left-column

代替製品

Primary Antibodies

AB89544

Anti-CCL28/MEC antibody [MM0153-9G34]

Western blot - Anti-CCL28/MEC antibody [MM0153-9G34] (AB89544)

  • 0
  • 0
Primary Antibodies

AB232837

Anti-CCL28/MEC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCL28/MEC antibody (AB232837)

  • 0
  • 0
Primary Antibodies

AB192600

Anti-CCL28/MEC antibody [EPR12933]

RabMAb|Recombinant

Western blot - Anti-CCL28/MEC antibody [EPR12933] (AB192600)

  • 0
  • 0

組合せ製品

Assay Kits

AB99988

Human CCL28 ELISA Kit

Sandwich ELISA - Human CCL28 ELISA Kit (AB99988)

  • 0
  • 0
Primary Antibodies

AB264467

Anti-CXCL14 antibody [EPR22807-28]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-CXCL14 antibody [EPR22807-28] (AB264467)

  • 0
  • 0
Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab231557 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CCL28 also known as MEC (Mucosae-associated epithelial chemokine) is a chemokine weighing around 12 kDa. It plays a mechanical role in mediating cell chemotaxis promoting the migration of cells towards it. This chemokine predominantly expresses in mucosal tissues including the salivary glands intestines and respiratory tract epithelia. CCL28 interacts specifically with chemokine receptors CCR10 and CCR3 guiding immune cells to these mucosal surfaces where they perform important immune functions.
Biological function summary

CCL28 plays an important role in mucosal immunity and is involved in the defense against pathogens in these environments. The chemokine attracts lymphocytes and neutrophils aiding in their positioning at mucosal sites. This activity assists in maintaining a balanced immune response preventing excessive inflammation while ensuring adequate pathogen clearance. CCL28 is not part of a larger protein complex but performs critical functions independently coordinating with other immune mediators for effective response.

Pathways

The function of CCL28 aligns with its involvement in immune signaling and mucosal defense pathways. The chemokine integrates into the immune response network working closely with other chemokines and cytokines like CCL27 and IL-8. It engages in the chemokine signaling pathway which regulates leukocyte migration and positioning. The interplay between CCL28 and these immune mediators ensures proper protection of mucosal surfaces from potential pathogens.

CCL28 holds significant relevance in inflammatory bowel disease (IBD) and allergic rhinitis. In IBD the chemokine contributes to the infiltration of immune cells into the inflamed gut mucosa where its interaction with other cytokines such as TNF-α exacerbates tissue inflammation. In allergic rhinitis CCL28 participates in recruiting eosinophils to the nasal mucosa often correlating with heightened inflammatory responses in these patients and cooperating with proteins like IL-5 to sustain the allergic reaction.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
See full target information CCL28
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:1161 PubMed36859428

2023

Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment.

Applications

Unspecified application

Species

Unspecified reactive species

Juntao Chen,Cuidi Xu,Kun Yang,Rifeng Gao,Yirui Cao,Lifei Liang,Siyue Chen,Shihao Xu,Ruiming Rong,Jina Wang,Tongyu Zhu

PloS one 16:e0258977 PubMed34679122

2021

Upregulation of a nuclear factor-kappa B-interacting immune gene network in mice cochleae with age-related hearing loss.

Applications

Unspecified application

Species

Unspecified reactive species

Kensuke Uraguchi,Yukihide Maeda,Junko Takahara,Ryotaro Omichi,Shohei Fujimoto,Shin Kariya,Kazunori Nishizaki,Mizuo Ando
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com