AB9849

Anti-CCL18 抗体

Name: Anti-CCL18 抗体 (ab9849) | Abcam
Brand: Abcam Limited
SKU: AB9849
Price: 75000 JPY
Availability: InStock

Anti-CCL18 antibody

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(4 Publications)

Rabbit Polyclonal CCL18 antibody. Suitable for ELISA, WB, sELISA and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Full Length Protein corresponding to Human CCL18.

別名を表示する

AMAC1, DCCK1, MIP4, PARC, SCYA18, CCL18, C-C motif chemokine 18, Alternative macrophage activation-associated CC chemokine 1, CC chemokine PARC, Dendritic cell chemokine 1, Macrophage inflammatory protein 4, Pulmonary and activation-regulated chemokine, Small-inducible cytokine A18, AMAC-1, DC-CK1, MIP-4

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

Unknown

軽鎖のタイプ

unknown

キャリアフリー

交差種

Human

アプリケーション

ELISA, sELISA, WB

applications

免疫原

Full Length Protein corresponding to Human CCL18. The exact immunogen used to generate this antibody is proprietary information.

P55774

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "To detect CCL18 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with an appropriate detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant CCL18. ." } } }

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

Reconstitute with 200µl of sterile water.

精製方法

Affinity purification Immunogen

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CCL18 also known as pulmonary and activation-regulated chemokine (PARC) is a chemokine protein with a molecular weight of about 8.8 kDa. It is mainly expressed in the lung but also found in lymph nodes and placenta. CCL18 is secreted by activated macrophages and dendritic cells. As a chemokine it plays a role in immune system signaling where it attracts immune cells like T lymphocytes. Researchers utilize CCL18 ELISA kits to accurately measure its levels in biological samples providing insight into its functions.

Biological function summary

CCL18 plays an important role in modulating immune responses and recruiting immune cells to sites of inflammation. It is not part of a larger complex but works closely with other components of the immune system. CCL18 influences the activity of monocytes and the differentiation of T cells which are essential for mounting effective defense against pathogens. In inflammatory conditions increased CCL18 levels suggest its importance in controlling the magnitude and duration of immune responses.

Pathways

CCL18 is involved in the immune response and inflammatory pathways. It works particularly in chemokine signaling pathways and shares functional relations with proteins like CCR3 and CCR6 which act as receptors for various chemokines. The binding of CCL18 to these receptors on targeted cells facilitates the chemotaxis of immune cells steering the immune response to appropriate areas in the body where they are needed.

CCL18 has known associations with pulmonary fibrosis and various cancers. In pulmonary fibrosis CCL18 levels correlate with disease severity and progression indicating its potential role as a biomarker. The protein interacts with other signaling molecules including collagen and matrix metalloproteinases driving the fibrotic process. In cancers especially breast cancer high CCL18 expression often corresponds to tumor progression and metastasis. These interactions highlight its relevance not only in disease progression but also as a target for therapeutic interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

See full target information CCL18

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 77:3605-3618 PubMed28512246

2017

Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Nie,Jianing Chen,Di Huang,Yandan Yao,Jiewen Chen,Lin Ding,Jiayi Zeng,Shicheng Su,Xue Chao,Fengxi Su,Herui Yao,Hai Hu,Erwei Song

Cancer research 77:3591-3604 PubMed28484077

2017

Epstein-Barr Virus-Induced VEGF and GM-CSF Drive Nasopharyngeal Carcinoma Metastasis via Recruitment and Activation of Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Di Huang,Shi-Jian Song,Zi-Zhao Wu,Wei Wu,Xiu-Ying Cui,Jia-Ning Chen,Mu-Sheng Zeng,Shi-Cheng Su

Cell research 27:461-482 PubMed28290464

2017

Blocking the recruitment of naive CD4 T cells reverses immunosuppression in breast cancer.

Applications

Species

Human

Shicheng Su,Jianyou Liao,Jiang Liu,Di Huang,Chonghua He,Fei Chen,LinBing Yang,Wei Wu,Jianing Chen,Ling Lin,Yunjie Zeng,Nengtai Ouyang,Xiuying Cui,Herui Yao,Fengxi Su,Jian-Dong Huang,Judy Lieberman,Qiang Liu,Erwei Song

Cancer cell 25:605-20 PubMed24823638

2014

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Shicheng Su,Qiang Liu,Jingqi Chen,Jianing Chen,Fei Chen,Chonghua He,Di Huang,Wei Wu,Ling Lin,Wei Huang,Jin Zhang,Xiuying Cui,Fang Zheng,Haiyan Li,Herui Yao,Fengxi Su,Erwei Song

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCL18 抗体

Anti-CCL18 antibody

Key facts

宿主種

クローン性

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

再構成

精製方法

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

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Abcam product promise