Anti-CCK4 抗体 (ab117412)
Key features and details
- Rabbit polyclonal to CCK4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CCK4 antibody
CCK4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CCK4 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Purified Human CCK4 protein, emulsified in complete adjuvant.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Proprietary component -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
The anti-serum was pre-cleared for tag protein and then affinity purified on immobilized PTK7 affinity chromatography. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab117412の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (3) |
1/500. Detects a band of approximately 133 kDa (predicted molecular weight: 93 kDa).
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| 特記事項 |
|---|
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WB
1/500. Detects a band of approximately 133 kDa (predicted molecular weight: 93 kDa). |
ターゲット情報
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機能
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. -
組織特異性
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
ドメイン
The protein kinase domain is predicted to be catalytically inactive. -
翻訳後修飾
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. -
細胞内局在
Membrane. Cell junction. Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. - Information by UniProt
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参照データベース
- Entrez Gene: 5754 Human
- Omim: 601890 Human
- SwissProt: Q13308 Human
- Unigene: 90572 Human
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別名
- 8430404F20Rik antibody
- CCK 4 antibody
- CCK-4 antibody
see all
画像
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Western blot - Anti-CCK4 antibody (ab117412)All lanes : Anti-CCK4 antibody (ab117412) at 1/500 dilution
Lane 1 : MCF7 cells extracts
Lane 2 : T4D7 cells extracts
Predicted band size: 93 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (0)
ab117412 は論文での使用が確認できていません。
