Anti-Cbl-c 抗体 (ab34750)
Key features and details
- Rabbit polyclonal to Cbl-c
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG
製品の概要
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製品名
Anti-Cbl-c antibody
Cbl-c 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Cbl-c -
由来種
Rabbit -
特異性
This affinity purified antibody is directed against human Cbl-c protein. A BLAST analysis was used to suggest that this antibody would react with Cbl-c from human and chimpanzee sources. Expect partial reactivity against mouse and rat sources of Cbl-c as ~83% sequence homology is on record for the immunogen sequence. Reactivity with Cbl-c from other sources has not been determined. No reactivity is expected with Cbl-a or Cbl-b.
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アプリケーション
適用あり: WBmore details -
種交差性
交差種: Recombinant fragment
交差が予測される動物種: Mouse, Rat, Human, Chimpanzee
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免疫原
Synthetic peptide:
PRKPRNAQPKVRLLK
, corresponding to amino acids 444-458 of Human Cbl-c -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 0.424% Potassium phosphate solution, 0.88% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
This affinity purified antibody is directed against human Cbl-c protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab34750の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 52 kDa.
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| 特記事項 |
|---|
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WB
1/500 - 1/3000. Predicted molecular weight: 52 kDa. |
ターゲット情報
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関連性
Cblc belongs to a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cblc is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitous). Cblc, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cblc knock out mice show no obvious phenotype. Thus, the physiological role of Cblc is not known. -
細胞内局在
Nuclear -
参照データベース
- Entrez Gene: 23624 Human
- Entrez Gene: 80794 Mouse
- Entrez Gene: 292699 Rat
- Omim: 608453 Human
- SwissProt: Q9ULV8 Human
- SwissProt: Q80XL1 Mouse
- SwissProt: G3V8H4 Rat
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別名
- Cas Br M (murine) ecotropic retroviral transforming sequence c antibody
- Cas Br M (murine) ectropic retroviral transforming sequence c antibody
- Casitas B lineage lymphoma c antibody
see all
画像
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Western blot - Anti-Cbl-c antibody (ab34750)All lanes : Anti-Cbl-c antibody (ab34750) at 1/500 dilution
Lanes 1 & 3 : Hek 293T cell lysate transfected with empty vector
Lanes 2 & 4 : Hek 293T cell lysate transfected with Cbl-c.
Predicted band size: 52 kDa
Observed band size: 52 kDa
The right panel shows western blotting after first immunoprecipitating with Rabbit anti- Cbl-c followed by immunoblotting.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab34750 は論文での使用が確認できていません。