AB2911

Anti-Caveolin-2 抗体

Name: Anti-Caveolin-2 抗体 (ab2911) | Abcam
Brand: Abcam Limited
SKU: AB2911
Rating: 4 (4 reviews)

Anti-Caveolin-2 antibody

(4 Reviews)

(12 Publications)

Rabbit Polyclonal Caveolin-2 antibody. Suitable for WB and reacts with Rat, Mouse samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Rat Cav2 aa 1-50.

別名を表示する

Caveolin-2, Cav2

2 Images

Unknown

Western blot - Anti-Caveolin-2 antibody (AB2911)

Western blot of caveolin-2 on rat skeletal muscle protein extract using ab2911.

All lanes:

Western blot - Anti-Caveolin-2 antibody (ab2911)

Predicted band size: 18 kDa

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Supplier Data

Western blot - Anti-Caveolin-2 antibody (AB2911)

All lanes:

Western blot - Anti-Caveolin-2 antibody (ab2911) at 2 µg/mL

Lane 1:

3T3-L1 lysate

Lane 2:

3T3-L1 differentiated to adipocytes

Lane 3:

Mouse Heart lysate

Lane 4:

Mouse Lung lysate

Lane 5:

Mouse Adipose lysate

Lane 6:

Mouse Spleen lysate

Secondary

All lanes:

Goat anti-Rabbit IgG (H+L) Superclonal Recombinant Secondary Antibody, HRP at 1/4000 dilution

Predicted band size: 18 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat, Mouse

アプリケーション

applications

免疫原

Synthetic Peptide within Rat Cav2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q2IBC5

特異性

Detects caveolin-2 from rat tissues. This antibody does not detect caveolin-1 or -3.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Can be blocked with Caveolin-2 peptide.</p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Can be blocked with Caveolin-2 peptide.</p>" }, "African bush elephant": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Caveolin-2 often referred to as CAV2 is a 20-22 kDa integral membrane protein and an important component of caveolae small invaginations in the plasma membrane. It is mainly expressed in adipocytes endothelial cells pneumocytes and some smooth muscle cells. CAV2 works together with other caveolins primarily caveolin-1 to form these flask-shaped invaginations which play roles in various cellular processes.

Biological function summary

Caveolin-2 participates in modulating cellular functions such as signal transduction cholesterol homeostasis and endocytosis. As part of the caveolae complex it cooperates with caveolin-1 to regulate lipid raft domains influencing the movement and function of molecules within the cell. The presence of caveolin-2 helps maintain the caveolae structure and is involved in cellular responses to mechanical stress.

Pathways

Caveolin-2 is implicated in the regulation of insulin signaling and the Ras-MAPK signaling pathway. In the insulin signaling pathway it forms complexes with caveolin-1 and other proteins like IRS-1 affecting glucose uptake in cells. In the Ras-MAPK pathway caveolin-2 interacts with signaling molecules associated with the pathway modulating cell proliferation and survival.

Caveolin-2 has been linked to cancer development and pulmonary disorders. Its interactions with caveolin-1 and other signaling proteins in cancer cells can influence tumor growth and metastasis. Additionally altered expression of caveolin-2 affects pulmonary disorders such as emphysema by impacting endothelial cell function. Understanding these connections helps in exploring potential therapeutic interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

See full target information Caveolin-2

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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular histology 54:67-75 PubMed36719565

2023

Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells.

Applications

Unspecified application

Species

Unspecified reactive species

Gongming Gao,Kewei Ren,Liang Chen,Xinru Li,Zitong Li,Yang Liu,Chenxi Ouyang,Hao Wang,Luming Nong,Hua Xie

Signal transduction and targeted therapy 5:75 PubMed32499481

2020

Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxue Yang,Liping Ma,Rong Wei,Tinghong Ye,JianKang Zhou,Maoyao Wen,Ruoting Men,Rami I Aqeilan,Yong Peng,Li Yang

American journal of physiology. Cell physiology : PubMed32348174

2020

Cardiomyoblast caveolin expression: Effects of simulated diabetes, α-linolenic acid and cell signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jake S Russell,Tia A Griffith,Jason N Peart,John P Headrick

Cancer cell international 20:55 PubMed32099528

2020

Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Jiao,Ting Han,Cuncun Yuan,Yiyi Liang,Jiujie Cui,Meng Zhuo,Liwei Wang

Frontiers in cellular neuroscience 11:253 PubMed28878626

2017

MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ole V Mortensen,Mads B Larsen,Susan G Amara

PloS one 8:e67300 PubMed23826261

2013

Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation.

Applications

Species

Unspecified reactive species

Lena Hoeke,Jutta Sharbati,Kamlesh Pawar,Andreas Keller,Ralf Einspanier,Soroush Sharbati

Experimental cell research 316:3182-96 PubMed20828556

2010

Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Linda Källquist,Hanna Rosén,Pontus Nordenfelt,Jero Calafat,Hans Janssen,Ann-Maj Persson,Markus Hansson,Inge Olsson

Canadian journal of physiology and pharmacology 88:73-6 PubMed20130741

2010

Caveolin-1 exists and may function in cardiomyocytes.

Applications

IHC-P

Species

Mouse

Woo Jung Cho,Ava K Chow,Richard Schulz,Edwin E Daniel

The Journal of biological chemistry 284:9955-64 PubMed19211560

2009

Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.

Applications

Species

Mouse

David W Zaas,Zachary D Swan,Bethany J Brown,Guojie Li,Scott H Randell,Simone Degan,Mary E Sunday,Jo Rae Wright,Soman N Abraham

Journal of cellular and molecular medicine 11:1069-86 PubMed17979883

2007

Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium.

Applications

Unspecified application

Species

Unspecified reactive species

Woo Jung Cho,Ava K Chow,Richard Schulz,Edwin E Daniel

View all publications

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