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リコンビナントRabMAb

Anti-Carma 1/CARD11 抗体 [EPR3177] (ab109310)

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Western blot - Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)
  • Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR3177] to Carma 1/CARD11
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-Carma 1/CARD11 antibody [EPR3177]
    Carma 1/CARD11 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR3177] to Carma 1/CARD11

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details
    適用なし: Flow Cyt,IHC-P or IP

  • 種交差性

    交差種: Human
    交差が予測される動物種: Mouse

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • K562 and Ramos cell lysates

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab109310の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 133 kDa).
特記事項
WB
1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 133 kDa).
追加情報
Is unsuitable for Flow Cyt,IHC-P or IP.

ターゲット情報

  • 機能

    Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

  • 組織特異性

    Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.

  • 配列類似性

    Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.

  • 翻訳後修飾

    Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.

  • 細胞内局在

    Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt

  • 参照データベース

    • 別名

      • 0610008L17Rik antibody
      • 2410011D02Rik antibody
      • Bcl10 interacting maguk protein 3 antibody
      • BIMP 3 antibody
      • BIMP3 antibody
      • CAR11_HUMAN antibody
      • CARD 11 antibody
      • CARD containing MAGUK protein 3 antibody
      • Card maguk protein 1 antibody
      • CARD-containing MAGUK protein 1 antibody
      • CARD11 antibody
      • CARD11 protein antibody
      • Carma 1 antibody
      • CARMA1 antibody
      • Caspase recruitment domain containing protein 11 antibody
      • Caspase recruitment domain family member 11 antibody
      • Caspase recruitment domain-containing protein 11 antibody
      • MGC133069 antibody
      see all

    画像

    • Western blot - Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)
      Western blot - Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)
      All lanes : Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310) at 1/1000 dilution

      Lane 1 : K562 cell lysates
      Lane 2 : Ramos cell lysates

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 133 kDa
      Observed band size: 130 kDa why is the actual band size different from the predicted?

    • Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)
      Anti-Carma 1/CARD11 antibody [EPR3177] (ab109310)

    参考文献 (0)

    ab109310 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab109310 は論文での使用が確認できていません。

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