AB123822

Anti-Capicua/CIC 抗体

Name: Anti-Capicua/CIC 抗体 (ab123822) | Abcam
Brand: Abcam Limited
SKU: AB123822
Price: 74000 JPY
Availability: InStock
Rating: 5 (2 reviews)

Anti-Capicua/CIC antibody

(2 Reviews)

(7 Publications)

Rabbit Polyclonal Capicua/CIC antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human CIC aa 1500 to C-terminus.

別名を表示する

KIAA0306, CIC, Protein capicua homolog

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IP, WB

applications

免疫原

Synthetic Peptide within Human CIC aa 1500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96RK0

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Bat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle|Do Not Freeze

style

left-column

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.

See full target information CIC

style

left-column

文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 44:3598-3608 PubMed40760094

2025

The CIC::DUX4 oncoprotein maintains DNA integrity through direct regulation of the catalytic subunit of DNA polymerase epsilon (POLE).

Applications

Unspecified application

Species

Unspecified reactive species

Zeinab Kosibaty,Cuyler Luck,Ross A Okimoto

Human molecular genetics 29:3249-3265 PubMed32964235

2020

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.

Applications

Unspecified application

Species

Unspecified reactive species

Ravi Chopra,David D Bushart,John P Cooper,Dhananjay Yellajoshyula,Logan M Morrison,Haoran Huang,Hillary P Handler,Luke J Man,Warunee Dansithong,Daniel R Scoles,Stefan M Pulst,Harry T Orr,Vikram G Shakkottai

Molecular cancer research : MCR 18:774-786 PubMed32029440

2020

c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Severa Bunda,Pardeep Heir,Annie Si Cong Li,Yasin Mamatjan,Gelareh Zadeh,Kenneth Aldape

OncoTargets and therapy 12:3595-3607 PubMed31190862

2019

miR-106b promotes proliferation and invasion by targeting Capicua through MAPK signaling in renal carcinoma cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lu-Jie Miao,Shu Yan,Qian-Feng Zhuang,Qing-Yan Mao,Dong Xue,Xiao-Zhou He,Jian-Ping Chen

Nature communications 10:661 PubMed30737375

2019

CIC protein instability contributes to tumorigenesis in glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Severa Bunda,Pardeep Heir,Julie Metcalf,Annie Si Cong Li,Sameer Agnihotri,Stefan Pusch,Mamatjan Yasin,Mira Li,Kelly Burrell,Sheila Mansouri,Olivia Singh,Mark Wilson,Amir Alamsahebpour,Romina Nejad,Bethany Choi,David Kim,Andreas von Deimling,Gelareh Zadeh,Kenneth Aldape

Neuron 97:1235-1243.e5 PubMed29526553

2018

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Maxime W C Rousseaux,Tyler Tschumperlin,Hsiang-Chih Lu,Elizabeth P Lackey,Vitaliy V Bondar,Ying-Wooi Wan,Qiumin Tan,Carolyn J Adamski,Jillian Friedrich,Kirk Twaroski,Weili Chen,Jakub Tolar,Christine Henzler,Ajay Sharma,Aleksandar Bajić,Tao Lin,Lisa Duvick,Zhandong Liu,Roy V Sillitoe,Huda Y Zoghbi,Harry T Orr

Genes & development 31:1456-1468 PubMed28827401

2017

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lucía Simón-Carrasco,Osvaldo Graña,Marina Salmón,Harrys K C Jacob,Alejandro Gutierrez,Gerardo Jiménez,Matthias Drosten,Mariano Barbacid

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Capicua/CIC 抗体

Anti-Capicua/CIC antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (7)

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise