Anti-Calpain 6 抗体 (ab76974)
Key features and details
- Rabbit polyclonal to Calpain 6
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Calpain 6 antibody -
製品の詳細
Rabbit polyclonal to Calpain 6 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
An 18 amino acid peptide from near the carboxy terminus of human Calpain 6.
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ポジティブ･コントロール
- WB: Rat lung tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab76974の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 75 kDa.
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| 特記事項 |
|---|
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WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 75 kDa. |
ターゲット情報
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機能
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. -
組織特異性
Expressed only in placenta. -
配列類似性
Belongs to the peptidase C2 family.
Contains 1 C2 domain.
Contains 1 calpain catalytic domain. -
細胞内局在
Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > spindle. During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle. - Information by UniProt
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参照データベース
- Entrez Gene: 83685 Rat
- SwissProt: O88501 Rat
- Unigene: 2862 Rat
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別名
- CALP M antibody
- Calpain-6 antibody
- Calpain-like protease X-linked antibody
see all
画像
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Western blot - Anti-Calpain 6 antibody (ab76974)Lane 1 : Anti-Calpain 6 antibody (ab76974) at 0.5 µg/ml
Lane 2 : Anti-Calpain 6 antibody (ab76974) at 1 µg/ml
All lanes : rat lung tissue lysate
Predicted band size: 75 kDa
Observed band size: 75 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab76974 は 2 報の論文で使用されています。
- Zhang YY et al. Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model. Int J Mol Med 48:N/A (2021). PubMed: 34435644
- Filali H et al. Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep. Vet Res 44:14 (2013). IHC-P ; Sheep . PubMed: 23497022