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AB59140

Anti-C8 抗体 [056B-373]

Anti-C8 antibody [056B-373]

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(1 Publication)

Mouse Monoclonal CO8A antibody. Suitable for Flow Cyt, ELISA, WB, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human C8G.

別名を表示する

Complement component C8 alpha chain, Complement component 8 subunit alpha, C8A

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

056B-373

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

IHC-Fr, WB, ELISA, Flow Cyt

applications

免疫原

Native Full Length Protein corresponding to Human C8G.

P07360

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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製品の詳細

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.1% Sodium azide Constituents: 99% Borate buffered saline
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

C8 also known as complement component C8 is a protein that plays an important role in the immune system's complement pathway. This protein has a mass of approximately 151 kDa and is expressed mainly in the liver. It circulates in the blood plasma until activated. C8 is an integral part of the membrane attack complex (MAC) which forms pores in the cell membranes of pathogens leading to their destruction. The protein occurs as a heterotrimer composed of three subunits: alpha (C8A) beta (C8B) and gamma (C8G) each contributing to its function.
Biological function summary

Complement component C8 participates in the terminal phase of the complement cascade. Within this process it integrates into the MAC a large protein complex that forms on the surface of pathogens. The formation of MAC creates transmembrane channels that lead to cell lysis. C8 is part of a larger group of proteins known as the complement system which works to clear pathogens from an organism. Its assembly and function are dependent on previous steps in the complement activation pathway particularly interaction with components like C9 for forming the complete MAC.

Pathways

The complement component C8 is actively involved in the complement activation classical pathway and the alternative pathway. These pathways are important for the immune response aiding in the opsonization of pathogens and promoting inflammation. In the context of these pathways C8 interacts with other complement proteins such as C5b which is necessary for the initiation of MAC assembly. This interaction ensures the proper functioning of the complement responses safeguarding against infections.

Mutations or deficiencies in complement component C8 can lead to immunological abnormalities such as recurrent bacterial infections notably Neisseria infections. Individuals with C8 deficiency may suffer from increased susceptibility to such infections due to impaired MAC formation. Furthermore an inappropriate activation or regulation of complement pathways involving C8 can contribute to autoimmune diseases like systemic lupus erythematosus where other complement proteins like C3 also play an important role. Understanding the functioning of C8 in these contexts is essential for developing therapeutic interventions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
See full target information C8A

追加のターゲット

C8G,C8B
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Food & nutrition research 61:1290740 PubMed28326005

2017

Bioactivity of food peptides: biological response of rats to bovine milk whey peptides following acute exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Soares Moura,Pablo Christiano Barboza Lollo,Priscila Neder Morato,Eder Muller Risso,Jaime Amaya-Farfan
View all publications
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組合せ製品

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