Anti-C5 抗体 [11F6] (ab17930)
Key features and details
- Mouse monoclonal [11F6] to C5
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
-
製品名
Anti-C5 antibody [11F6]
C5 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [11F6] to C5 -
由来種
Mouse -
特異性
ab17930 reacts with C5 in normal human plasma (PEG precipitated C5) in non reduced form only. No reaction is seen with plasma from C5 deficient patients. -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Human -
免疫原
Full length native C5 protein, isolated from human plasma.
-
エピトープ
Epitope specificity differs from that of ab17457 but slightly overlaps as determined by inhibition ELISA. -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
11F6 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17930の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ELISA | (1) |
Use at an assay dependent concentration.
|
WB |
Use at an assay dependent concentration. Predicted molecular weight: 188 kDa.
Recognises C5 in non-reduced form only. |
特記事項 |
---|
ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 188 kDa. Recognises C5 in non-reduced form only. |
ターゲット情報
-
機能
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). -
関連疾患
Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). -
配列類似性
Contains 1 anaphylatoxin-like domain.
Contains 1 NTR domain. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 727 Human
- Omim: 120900 Human
- SwissProt: P01031 Human
- Unigene: 494997 Human
-
別名
- Anaphylatoxin C5a analog antibody
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
- C5 antibody
see all
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (0)
ab17930 は論文での使用が確認できていません。