AB243827

Anti-C4orf27 抗体

Name: Anti-C4orf27 抗体 (ab243827) | Abcam
Brand: Abcam Limited
SKU: AB243827
Price: 90000 JPY
Availability: InStock

Anti-C4orf27 antibody

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(1 Publication)

Rabbit Polyclonal C4orf27 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HPF1 aa 50-200.

別名を表示する

C4orf27, HPF1, Histone PARylation factor 1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-C4orf27 antibody (AB243827)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-C4orf27 antibody (AB243827)

Human cell line U-251 stained for C4orf27 using ab243827 at 2 μg/ml in Immunocytochemistry/immunofluorescence analysis.

Supplier Data

Western blot - Anti-C4orf27 antibody (AB243827)

All lanes:

Western blot - Anti-C4orf27 antibody (ab243827) at 0.4 µg/mL

All lanes:

MOLT-4 (Human lymphoblastic leukemia cell line) cell lysate

Predicted band size: 39 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human HPF1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NWY4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

C4orf27 also known as UPF0710 protein C4orf27 is a protein encoded by the C4orf27 gene. It has a molecular mass of approximately 14 kDa. The C4orf27 protein's mechanical function is not fully understood but it is believed to have a role in cellular processes due to its conserved sequences. Expression of C4orf27 is observed in various tissues including the liver kidney and brain suggesting its involvement in multiple physiological functions.

Biological function summary

The function of C4orf27 remains unspecified but appears to be involved in cellular homeostasis and metabolism. It is hypothesized to participate in intracellular signaling pathways although it does not form part of any well-studied protein complex. Researchers continue to investigate its specific biological roles and interactions within the cell due to its broad expression pattern.

Pathways

C4orf27 may interact with cellular signaling and metabolic pathways. While its direct involvement in specific pathways remains under study it shows potential interactions with pathways such as the mitochondrial function and oxidative phosphorylation. Proteins such as COX4I1 involved in the electron transport chain may relate to C4orf27 through these pathways suggesting a role in energy utilization and cellular stress responses.

Research is ongoing to understand C4orf27's contributions to pathological states. Initial studies suggest associations with metabolic disorders and neurodegenerative diseases such as Alzheimer's disease. It may interact with proteins like APP (Amyloid precursor protein) through oxidative stress pathways possibly linking it to the pathogenesis of neurodegeneration. Further research will clarify the relevance of C4orf27 in these diseases aiming to discover potential therapeutic implications.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response (PubMed : 28190768, PubMed : 29480802, PubMed : 29954836, PubMed : 32028527, PubMed : 32939087, PubMed : 33186521, PubMed : 33589610, PubMed : 33683197, PubMed : 34108479, PubMed : 34210965, PubMed : 34486521, PubMed : 34625544, PubMed : 34732825, PubMed : 34795260, PubMed : 34874266). Initiates the repair of double-strand DNA breaks : recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins (PubMed : 28190768, PubMed : 29480802, PubMed : 29954836, PubMed : 32028527, PubMed : 32939087, PubMed : 33589610, PubMed : 33683197, PubMed : 34486521, PubMed : 34625544, PubMed : 34732825, PubMed : 34795260, PubMed : 34874266). Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed : 27067600, PubMed : 28190768, PubMed : 32939087, PubMed : 33589610). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed : 29480802). HPF1 acts by completing the active site of PARP1 and PARP2 : forms a composite active site composed of residues from HPF1 and PARP1 or PARP2 (PubMed : 32028527, PubMed : 33589610). While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed : 33683197, PubMed : 34732825, PubMed : 34795260). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed : 29954836, PubMed : 30257210).

See full target information HPF1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular histology 56:144 PubMed40285932

2025

Identification of the oncogenic role of centromere protein M in non-small cell lung cancer via CDC20/MYBL2/Wnt signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Wu,Jun Li,Haoyu Wang,Xu Chang,Qinglong Kong

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C4orf27 抗体

Anti-C4orf27 antibody

Immunocytochemistry/ Immunofluorescence - Anti-C4orf27 antibody (AB243827)

Western blot - Anti-C4orf27 antibody (AB243827)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

組合せ製品

Primary Antibodies

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Abcam product promise