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AB220962

Anti-C11orf84 抗体

Anti-C11orf84 antibody

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(2 Publications)

Rabbit Polyclonal C11orf84 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SPINDOC aa 200-350.

別名を表示する

C11orf84, SPINDOC, Spindlin interactor and repressor of chromatin-binding protein, SPIN1-docking protein, SPIN-DOC

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-C11orf84 antibody (AB220962)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-C11orf84 antibody (AB220962)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized A431 cells labeling C11orf84 with ab220962 at 4 μg/ml. Antibody staining is shown in green.

Western blot - Anti-C11orf84 antibody (AB220962)
  • WB

Supplier Data

Western blot - Anti-C11orf84 antibody (AB220962)

All lanes:

Western blot - Anti-C11orf84 antibody (ab220962) at 1/100 dilution

All lanes:

RT4 cell line

Predicted band size: 41 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SPINDOC aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q9BUA3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

C11orf84 also known as chromosome 11 open reading frame 84 is a lesser-known protein consisting of 242 amino acids with a predicted mass of approximately 27 kDa. Present in many tissues C11orf84 shows higher expression in the brain indicating a potential role linked to neurological processes. The understanding of this protein's exact mechanical functions is limited but its conservation across species suggests significance in cellular actions.
Biological function summary

C11orf84 interacts within cellular systems and possibly takes part in developing cellular structure and signaling. Reports suggest that it may act within multi-protein complexes but precise details on its complex associations are currently understudied. The presence of C11orf84 is consistent with proteins involved in maintaining cellular organization and perhaps signal transduction pointing to a wider involvement in cell biology.

Pathways

Established connections hint that C11orf84 may have a role in neurological pathways such as neural development or synaptic modulation. While direct association within these pathways requires further research C11orf84's expression in the brain links it to proteins like NLGN1 and SHANK3 known for their roles in neural signaling pathways. These connections suggest that C11orf84 might engage in modulating synaptic adherence and signaling efficiency.

Investigations into C11orf84 suggest potential links to neurological conditions such as autism spectrum disorders and schizophrenia. The commonness of the protein within the brain ties it to neuropsychiatric conditions where dysregulation impacts brain function. Its relation to other proteins like NRG1 which play roles in cognitive disorders provides a starting point for understanding how C11orf84 might contribute to these conditions. Further studies are necessary to clarify the role of C11orf84 in disease pathogenesis and if it represents a potential therapeutic target.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed : 33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed : 34737271).
See full target information SPINDOC
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 300:107783 PubMed39303913

2024

Downregulation of the mA reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou

OncoTargets and therapy 15:555-570 PubMed35611367

2022

is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wangxia Tong,Lilan Yang,Li Liu,Xudong Liu,Ning Luo
View all publications
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