AB192925

Anti-BVR 抗体

Name: Anti-BVR 抗体 (ab192925) | Abcam
Brand: Abcam Limited
SKU: AB192925
Price: 75000 JPY
Availability: InStock

Anti-BVR antibody

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(3 Publications)

Rabbit Polyclonal BVR antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human BLVRA aa 50-150.

別名を表示する

BLVR, BVR, BLVRA, Biliverdin reductase A, BVR A, Biliverdin-IX alpha-reductase

2 Images

Supplier Data

Immunoprecipitation - Anti-BVR antibody (AB192925)

Detection of BVR in Immunoprecipitates of 293T whole cell lysates (1 mg for IP, 20% of IP loaded) using ab192925 at 6 μg/reaction for IP and 1μg/ml for WB detection.

Detection : Chemiluminescence with an exposure time of 3 minutes.

All lanes:

Immunoprecipitation - Anti-BVR antibody (ab192925)

Predicted band size: 33 kDa

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Supplier Data

Western blot - Anti-BVR antibody (AB192925)

All lanes:

Western blot - Anti-BVR antibody (ab192925) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 33 kDa

true

Exposure time: 3min

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, IP

applications

免疫原

Synthetic Peptide within Human BLVRA aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

P53004

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab192925 was affinity purified using an epitope specific to BVR immobilized on solid support.

バッファー組成

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The BVR protein known in full form as Biliverdin Reductase plays an essential mechanical role in the conversion of biliverdin to bilirubin. It exists as two main isoforms BVR-A and BVR-B with molecular masses approximately of 33 kDa. BVR is widely expressed in various tissues with higher levels found in liver kidney and spleen. As an enzyme its main function centers around the redox cycle between biliverdin and bilirubin providing an antioxidant defense mechanism.

Biological function summary

BVR influences cell signaling and growth processes acting as a multifunctional enzyme beyond its primary reductive activity. It participates in the MAPK and PI3K/Akt signaling pathways acting both as a kinase and phosphatase which affects transcription factor regulation. BVR is also involved in heme metabolism working in conjunction with heme oxygenase to recycle heme a vital cellular molecule.

Pathways

BVR significantly contributes to the antioxidative and anti-inflammatory pathways. It operates within the heme catabolic pathway and the MAPK signaling cascade linking to proteins like heme oxygenase-1 (HO-1) and the transcription factor Nrf2. These pathways support cell response to oxidative stress and regulate gene expression in response to environmental stressors.

BVR is associated with conditions such as jaundice and chronic inflammation-oriented diseases. Its interaction with proteins like heme oxygenase-1 (HO-1) elevates its importance in managing oxidative stress-related disorders. Disruption in BVR function or expression can influence bilirubin metabolism potentially leading to hyperbilirubinemia and contributing to inflammatory disease development through altered cell signaling.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed : 10858451, PubMed : 7929092, PubMed : 8424666, PubMed : 8631357). Does not reduce bilirubin IXbeta (PubMed : 10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed : 7929092, PubMed : 8424666, PubMed : 8631357). NADPH, however, is the probable reactant in biological systems (PubMed : 7929092).

See full target information BLVRA

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

mBio 16:e0333124 PubMed39611845

2024

Coatomer complex I is required for the transport of SARS-CoV-2 progeny virions from the endoplasmic reticulum-Golgi intermediate compartment.

Applications

Unspecified application

Species

Unspecified reactive species

Ai Hirabayashi,Yukiko Muramoto,Toru Takenaga,Yugo Tsunoda,Mayumi Wakazaki,Mayuko Sato,Yoko Fujita-Fujiharu,Norimichi Nomura,Koji Yamauchi,Chiho Onishi,Masahiro Nakano,Kiminori Toyooka,Takeshi Noda

Biomolecules & therapeutics 31:674-681 PubMed37558633

2023

Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Keun Soo Ahn,Koo Jeong Kang,Yong Hoon Kim,Tae-Seok Kim,Kwang Bum Cho,Hye Soon Kim,Won-Ki Baek,Seong-Il Suh,Jin-Yi Han

American journal of cancer research 11:4844-4865 PubMed34765296

2021

LncRNA NR2F2-AS1 induces epithelial-mesenchymal transition of non-small cell lung cancer by modulating BVR/ATF-2 pathway via regulating miR-545-5p/c-Met axis.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Liu,Qun-Gen Li,Yang Zhou,Ying-Yue Cao,Zi-Xin Wei,Ying-Hua Jin,Xin Wang,Ying-Ying Chen,Li Qi,Jian-Xiong Geng,Fang Liu

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-BVR 抗体

Anti-BVR antibody

Immunoprecipitation - Anti-BVR antibody (AB192925)

Western blot - Anti-BVR antibody (AB192925)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise