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Anti-Butyrylcholinesterase 抗体 [OTI4C12] (ab117960)

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Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (ab117960)

    Key features and details

    • Mouse monoclonal [OTI4C12] to Butyrylcholinesterase
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG1

    製品の概要

    • 製品名

      Anti-Butyrylcholinesterase antibody [OTI4C12]
      Butyrylcholinesterase 一次抗体 製品一覧

    • 製品の詳細

      Mouse monoclonal [OTI4C12] to Butyrylcholinesterase

    • 由来種

      Mouse

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Recombinant full length protein corresponding to Human Butyrylcholinesterase. Produced in HEK293T cells (NP_000046).
      Database link: P06276

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • ポジティブ･コントロール

      • WB: HEK-293T cell lysate transfected with pCMV6-ENTRY butyrylcholinesterase cDNA.

    • 特記事項

      Clone OTI4C12 (formerly 4C12).

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab117960の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    WB
    1/2000. Predicted molecular weight: 68 kDa.
    特記事項
    WB
    1/2000. Predicted molecular weight: 68 kDa.

    ターゲット情報

    • 機能

      Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

    • 組織特異性

      Detected in blood plasma (at protein level). Present in most cells except erythrocytes.

    • 関連疾患

      Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

    • 配列類似性

      Belongs to the type-B carboxylesterase/lipase family.

    • 細胞内局在

      Secreted.
    • Information by UniProt

    • 参照データベース

      • 別名

        • Acylcholine acylhydrolase antibody
        • BCHE antibody
        • Butyrylcholine esterase antibody
        • CHE1 antibody
        • CHE2 antibody
        • CHLE_HUMAN antibody
        • Choline esterase II antibody
        • Cholinesterase (serum) 2 antibody
        • Cholinesterase 1 antibody
        • Cholinesterase antibody
        • E1 antibody
        • Pseudocholinesterase antibody
        • Pseudocholinesterase E1 antibody
        see all

      画像

      • Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (ab117960)
        Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (ab117960)
        All lanes : Anti-Butyrylcholinesterase antibody [OTI4C12] (ab117960) at 1/2000 dilution

        Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate transfected with pCMV6-ENTRY control
        Lane 2 : HEK-293T cell lysate transfected with pCMV6-ENTRY Butyrylcholinesterase cDNA

        Lysates/proteins at 5 µg per lane.

        Predicted band size: 68 kDa

      プロトコール

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      参考文献 (0)

      ab117960 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab117960 は論文での使用が確認できていません。

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