Anti-Butyrylcholinesterase 抗体 [3E8] (ab17246)
![ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)](https://www.abcam.co.jp/ps/products/17/ab17246/Images/ab17246-283478-anti-butyrylcholinesterase-antibody-3e8-elisa.jpg "ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)")
Key features and details
- Mouse monoclonal [3E8] to Butyrylcholinesterase
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Butyrylcholinesterase antibody [3E8]
Butyrylcholinesterase 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [3E8] to Butyrylcholinesterase -
由来種
Mouse -
特異性
No reaction is seen with acetylcholinesterase from human nervous tissue and erythrocytes. -
アプリケーション
適用あり: ELISAmore details
適用なし: WB -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human Butyrylcholinesterase. (Isolated from human plasma).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
3E8 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17246の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
1/8000.
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| 特記事項 |
|---|
|
ELISA
1/8000. |
ターゲット情報
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機能
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. -
組織特異性
Detected in blood plasma (at protein level). Present in most cells except erythrocytes. -
関連疾患
Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. -
配列類似性
Belongs to the type-B carboxylesterase/lipase family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 590 Human
- Omim: 177400 Human
- SwissProt: P06276 Human
- Unigene: 420483 Human
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別名
- Acylcholine acylhydrolase antibody
- BCHE antibody
- Butyrylcholine esterase antibody
see all
画像
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ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)
Calibration curve of a sandwich assay for Butyrylcholinesterase using ab17246 as the capture antibody and a biotinylated detection antibody.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab17246 は 3 報の論文で使用されています。
- Li J et al. Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nat Commun 12:896 (2021). PubMed: 33563994
- Sinclair LI et al. Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas. Alzheimers Res Ther 11:80 (2019). PubMed: 31511061
- Yang M et al. Simultaneous detection of dual biomarkers from humans exposed to organophosphorus pesticides by combination of immunochromatographic test strip and ellman assay. Biosens Bioelectron 104:39-44 (2018). PubMed: 29306031