Anti-BTNL2 抗体 [EPR12252] (ab181198)

Negative regulator of T cell proliferation.

Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.

Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.

Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 3 Ig-like V-type (immunoglobulin-like) domains.

Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.