Anti-BRMS1 抗体 (ab172430)
Key features and details
- Mouse polyclonal to BRMS1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-BRMS1 antibody
BRMS1 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to BRMS1 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow
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免疫原
Recombinant full length protein within Human BRMS1 aa 1 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (NP_056214.1).
Database link: Q9HCU9 -
ポジティブ･コントロール
- BRMS1 transfected 293T cell line lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Constituent: 100% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab172430の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa.
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. |
ターゲット情報
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機能
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. -
組織特異性
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. -
配列類似性
Belongs to the BRMS1 family. -
細胞内局在
Nucleus. Cytoplasm. Predominantly nuclear. - Information by UniProt
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参照データベース
- Entrez Gene: 615952 Cow
- Entrez Gene: 25855 Human
- Entrez Gene: 107392 Mouse
- Entrez Gene: 293668 Rat
- Omim: 606259 Human
- SwissProt: Q1LZE0 Cow
- SwissProt: Q9HCU9 Human
- SwissProt: Q99N20 Mouse
see all -
別名
- AV003220 antibody
- AW554636 antibody
- Breast cancer metastasis suppressor 1 antibody
see all
画像
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Western blot - Anti-BRMS1 antibody (ab172430)All lanes : Anti-BRMS1 antibody (ab172430) at 1 µg/ml
Lane 1 : BRMS1 transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 15 µl per lane.
Predicted band size: 28 kDa
データシートおよび資料
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Datasheet download
参考文献 (1)
ab172430 は 1 報の論文で使用されています。
- Zhou C et al. N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1. EBioMedicine 59:102955 (2020). PubMed: 32853985
