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AB1072

Anti-Bovine Papilloma Virus E2 抗体 [5H4]

Anti-Bovine Papilloma Virus E2 antibody [5H4]

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(1 Publication)

Mouse Monoclonal VE2 antibody. Suitable for ICC/IF, IP, ELISA and reacts with Recombinant full length protein - Bovine papillomavirus, Bovine papillomavirus samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Deltapapillomavirus 4 E2.

別名を表示する

Regulatory protein E2, E2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Bovine Papilloma Virus E2 antibody [5H4] (AB1072)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Bovine Papilloma Virus E2 antibody [5H4] (AB1072)

Immunofluorescent staining of U2OS cells expressing BPV E2 protein with ab1072. The cells were counter-stained with DAPI, and the upper shows an image taken with illumination at both 460 nm and 488 nm, whereas the lower image shows illumination at 488 nm.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

5H4

アイソタイプ

IgG1

キャリアフリー

No

交差種

Bovine papillomavirus

アプリケーション

ICC/IF, ELISA, IP

applications

免疫原

Recombinant Full Length Protein corresponding to Deltapapillomavirus 4 E2.

P03122

エピトープ

Conformational

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Bovine papillomavirus": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Bovine papillomavirus": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-2 µg/mL", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Bovine Papilloma Virus E2 (BPV E2) is an important regulatory protein involved in the lifecycle of the Bovine Papilloma Virus. It also goes by alternate names such as E2 protein or Papilloma E2 antigen. The E2 protein has a mass of approximately 40 kDa. It is expressed during the early phase of viral infection within the nucleus of infected cells. BPV E2 plays a mechanical role by binding to DNA at specific sequences facilitating viral replication and transcription.
Biological function summary

BPV E2 functions as a transcription factor that regulates the expression of viral genes. It is part of a larger complex with other viral proteins such as E1 with which it cooperates to initiate viral replication. E2’s control over viral gene expression allows it to modulate the virus's ability to replicate and persist in host cells influencing the viral lifecycle and maintenance.

Pathways

BPV E2 is integral in the regulation of pathways related to viral replication and transcription. It is closely involved in the papillomavirus replication pathway interacting with proteins such as E1 to initiate DNA replication. Another relevant pathway includes transcriptional regulation where E2 controls the expression of various viral genes contributing to papillomavirus pathogenesis.

BPV E2 is connected to bovine papillomatosis a condition characterized by wart formation in cattle. This disorder arises due to the uncontrolled proliferation of infected cells mediated by the viral replication facilitated by BPV E2. Its interaction with the E1 protein is essential for the viral replication that leads to disease progression. Understanding E2 and its role offers potential insights into therapeutic targets using bovine antibodies and possibly developing anti-papilloma strategies in bovine species.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
See full target information E2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Veterinary dermatology 32:268-e74 PubMed33908122

2021

A case series of canine cutaneous inverted papilloma with one case showing evidence of recurrence.

Applications

Unspecified application

Species

Unspecified reactive species

Teresa M S A Boehm,Sonya Bettenay,Wolf von Bomhard,Monir Majzoub-Altweck,Christoph J Klinger,Ralf S Mueller
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

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