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AB67126

Anti-Borealin/CDCA8 抗体

Anti-Borealin/CDCA8 antibody

2

(4 Reviews)

|

(2 Publications)

Mouse Polyclonal Borealin/CDCA8 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CDCA8.

別名を表示する

PESCRG3, CDCA8, Borealin, Cell division cycle-associated protein 8, Dasra-B, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

Yes

交差種

Human

アプリケーション

WB

applications

免疫原

Native Full Length Protein corresponding to Human CDCA8.

Q53HL2

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代替製品

Primary Antibodies

AB74473

Anti-Borealin/CDCA8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Borealin/CDCA8 antibody (AB74473)

  • 5
  • 1

組合せ製品

Primary Antibodies

AB81283

Anti-AKT1 (phospho S473) antibody [EP2109Y]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKT1 (phospho S473) antibody [EP2109Y] (AB81283)

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  • 10
Primary Antibodies

AB133327

Anti-CDK1 antibody [EPR165]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-CDK1 antibody [EPR165] (AB133327)

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  • 4
Primary Antibodies

AB185622

Anti-Cyclin B2/CCNB2 antibody [R17985]

RabMAb|Recombinant|20ul selling size|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin B2/CCNB2 antibody [R17985] (AB185622)

  • 0
  • 0
Primary Antibodies

AB32107

Anti-Histone H3 (phospho S10 + T11) antibody [E173]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H3 (phospho S10 + T11) antibody [E173] (AB32107)

  • 5
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Borealin also known as CDCA8 is a component of the chromosomal passenger complex (CPC) with a mass of approximately 22 kDa. This protein facilitates proper chromosome segregation and cytokinesis during cell division. It is mainly expressed in proliferating cells especially in tissues undergoing frequent cell cycles like testis and tumor tissues. Borealin localizes to the centromeres and the spindle midzone during mitosis highlighting its mechanical involvement in maintaining chromosome alignment and proper cell division.
Biological function summary

Borealin serves as an important element in ensuring accurate mitosis. It functions as an integral part of the chromosomal passenger complex which also includes Aurora B kinase Survivin and INCENP. This complex regulates chromosome-microtubule interactions and cytokinesis. Borealin interacts with other CPC components to ensure stability and proper localization of the complex facilitating important mitotic functions. This highlights Borealin's biological role in maintaining genomic stability.

Pathways

Borealin integrates into the cell cycle and mitotic pathways. These pathways include the regulation of Aurora B kinase and its associated proteins such as Survivin and INCENP playing a critical role in chromosome condensation spindle assembly and cytokinesis. In the mitotic pathway Borealin's interaction with the CPC allows for precise coordination of mitotic events providing a framework for successful cell division and its associated processes.

Abnormalities in Borealin function are linked to cancer and chromosomal instability syndromes. Disrupted Borealin expression or function can lead to abnormal mitosis and contribute to tumorigenesis. Research suggests that Borealin alterations may relate to other proteins involved in cancer including Aurora B kinase influencing cancer progression through enhanced genomic instability or proliferation rates. Understanding Borealin's contribution to these diseases may offer new avenues for therapeutic exploration in targeting cancer cell division.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
See full target information CDCA8
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 12:13437-13449 PubMed33408516

2020

Identification of Core Genes Involved in the Metastasis of Clear Cell Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Peng,Yahui Wang,Likai Mao,Fang Fang,Han Guan

Nature communications 7:13853 PubMed28004745

2016

PKCɛ switches Aurora B specificity to exit the abscission checkpoint.

Applications

ICC/IF, WB

Species

Unspecified reactive species, Unspecified reactive species

Tanya Pike,Nicola Brownlow,Svend Kjaer,Jeremy Carlton,Peter J Parker
View all publications
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Abcam product promise

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