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  1. Link

    products/primary-antibodies/bmpr2-antibody-mm0060-9a10-ab78422.pdf

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Signal Transduction Protein Phosphorylation Ser / Thr Kinases Other Kinases
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Anti-BMPR2 抗体 [MM0060-9A10] (ab78422)

  • Datasheet
Submit a review Q&A (5)References (13)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)
  • Flow Cytometry - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)

Key features and details

  • Mouse monoclonal [MM0060-9A10] to BMPR2
  • Suitable for: Flow Cyt, IHC-P
  • Reacts with: Human
  • Isotype: IgG1

こちらの製品もご検討ください

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Anti-ALK-1 antibody [MM0015-8G33] (ab51870)

関連製品

製品の概要

  • 製品名

    Anti-BMPR2 antibody [MM0060-9A10]
    BMPR2 一次抗体 製品一覧
  • 製品の詳細

    Mouse monoclonal [MM0060-9A10] to BMPR2
  • 由来種

    Mouse
  • 特異性

    ab78422 detects BMPR2. No cross reactivity was found to BMPR1A and BMPR1B.
  • アプリケーション

    適用あり: Flow Cyt, IHC-Pmore details
  • 種交差性

    交差種: Human
  • 免疫原

    Recombinant human BMPR2 extracellular domain

  • ポジティブ・コントロール

    • IHC-P: Human placenta tissue.
  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid
  • 保存方法

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー

    Constituent: PBS
  • Concentration information loading...
  • 精製度

    Protein G purified
  • 特記事項(精製)

    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate buffered saline (PBS).
  • ポリ/モノ

    モノクローナル
  • クローン名

    MM0060-9A10
  • アイソタイプ

    IgG1
  • 研究分野

    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases
    • Signal Transduction
    • Growth Factors/Hormones
    • TGF
    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • Structures
    • Bone
    • Stem Cells
    • Signaling Pathways
    • TGF beta
    • Surface Molecules
    • Stem Cells
    • Mesenchymal Stem Cells
    • Surface Molecules
    • Cardiovascular
    • Heart
    • Hypertrophy
    • Other

関連製品

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed (ab96879)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
    • Mouse IgG1, Kappa Monoclonal [B11/6] - Isotype Control (ab91353)

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab78422の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
Flow Cyt
Use 1-2µg for 106 cells.

(methanol or paraformaldehyde fixed cells)

 

 

 

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

IHC-P
1/50 - 1/200. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. We recommend to use Proteinase K for the enzymatic antigen retrieval.
特記事項
Flow Cyt
Use 1-2µg for 106 cells.

(methanol or paraformaldehyde fixed cells)

 

 

 

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

IHC-P
1/50 - 1/200. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. We recommend to use Proteinase K for the enzymatic antigen retrieval.

ターゲット情報

  • 機能

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
  • 組織特異性

    Highly expressed in heart and liver.
  • 関連疾患

    Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
    Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.
  • 配列類似性

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在

    Membrane.
  • Target information above from: UniProt accession Q13873 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 参照データベース

    • Entrez Gene: 659 Human
    • Omim: 600799 Human
    • SwissProt: Q13873 Human
    • Unigene: 471119 Human
    • 別名

      • BMP type II receptor antibody
      • BMP type-2 receptor antibody
      • BMPR 2 antibody
      • BMPR 3 antibody
      • BMPR II antibody
      • BMPR-2 antibody
      • BMPR-II antibody
      • Bmpr2 antibody
      • BMPR2_HUMAN antibody
      • BMPR3 antibody
      • BMPRII antibody
      • BMR 2 antibody
      • BMR2 antibody
      • Bone morphogenetic protein receptor type 2 antibody
      • Bone morphogenetic protein receptor type II antibody
      • Bone morphogenetic protein receptor type-2 antibody
      • Bone morphogenic protein receptor type II serine threonine kinase antibody
      • BRK 3 antibody
      • BRK3 antibody
      • PPH 1 antibody
      • PPH1 antibody
      • Serine threonine kinase type II activin receptor like kinase antibody
      • T ALK antibody
      • TALK antibody
      • Type II activin receptor like kinase antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)

      ab78422 at 1/200 dilution, staining BMPR2 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

    • Flow Cytometry - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)
      Flow Cytometry - Anti-BMPR2 antibody [MM0060-9A10] (ab78422)
      Overlay histogram showing HepG2 cells stained with ab78422 (red line). The cells were fixed with methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab78422, 2µg/1x106 cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HepG2 cells fixed with 4% paraformaldehyde (10 min) used under the same conditions.

      Please note that Abcam does not have data for use of this antibody on non-fixed cells. We welcome any customer feedback.

    プロトコール

    • Flow cytometry protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    データシートおよび資料

    • Datasheet download

      Download

    参考文献 (13)

    ab78422 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab78422 は 13 報の論文で使用されています。

    • Schneider P  et al. CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia. Int J Mol Sci 24:N/A (2023). PubMed: 37686014
    • Shi XF  et al. Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7. Bioengineered 13:8538-8547 (2022). PubMed: 35331081
    • Wu CK  et al. BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation. Sci Rep 12:16310 (2022). PubMed: 36175474
    • Ren T  et al. Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. Cell Death Dis 10:261 (2019). PubMed: 30886151
    • Wang S  et al. BMPR2 and HIF1-aoverexpression in resected osteosarcoma correlates with distant metastasis and patient survival. Chin J Cancer Res 29:447-454 (2017). PubMed: 29142464
    View all Publications for this product

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    1-5 of 5 Abreviews or Q&A

    Question

    For how long the antigen retrieval step is recommended?

    Read More

    Abcam community

    Verified customer

    Asked on Feb 19 2013

    Answer

    Thank you for contacting us.

    We have used Proteinase K (20ug/ml in PBS) at room temperature for 20-30 minutes as antigen retrieval method. We however recommend customer trying a rage of time e.g. 5, 10, 15 or 20 mins for optimal results.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Feb 19 2013

    Question

    Customer kindly contacted us regarding double staining via IHC-P.

    Read More

    Abcam community

    Verified customer

    Asked on Dec 06 2012

    Answer

    Thank you for contacting Abcam.

    We recently discussed your experiment double staining with ab28364 and ab78422 via IHC-P. We talked about attempting both an enzymatic (Proteinase K, 37oC) and heat mediated (Citrate buffer, 100oC) antigen retrieval to see which gives you a better signal to background ratio for both antibodies. We also mentioned the necessity of the cooling step after antigen retrieval to allow the proteins to fold back into their native conformation, while the slide heating prior to deparrafinization and overnight cycling for rehydration are generally not necessary.

    I have included a link below to our IHC-P protocol guide
    https://www.abcam.com/ps/pdf/protocols/ihc_p.pdf

    Citrate buffer:
    10X ab64214: https://www.abcam.com/10x-citrate-buffer-ph-6-0-ab64214.html
    100X ab64236: https://www.abcam.com/100x-citrate-buffer-ph-6-0-ab64236.html

    We also discussed our anti-mouse and anti-rabbit secondary antibodies. I have included a link for both of those below. You will want to make sure the conjugated fluorophores have different emission wavelengths:
    anti-mouse IgG: https://www.abcam.com/Search?AppliedFacets.FacetProductType=Secondary+antibodies&AppliedFacets.FacetTargetName=IgG&AppliedFacets.FacetTargetName=IgG1&AppliedFacets.FacetReactivity=Mouse&IsFacetsOnly=False&PageNumber=1&Keywords[0]=anti-mouse&X-Requested-With=XMLHttpRequest

    IgG anti-rabbit IgG: https://www.abcam.com/Search?AppliedFacets.FacetProductType=Secondary+antibodies&AppliedFacets.FacetTargetName=IgG&AppliedFacets.FacetReactivity=Rabbit&IsFacetsOnly=False&PageNumber=1&Keywords[0]=anti-rabbit&X-Requested-With=XMLHttpRequest

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

    Read More

    Abcam Scientific Support

    Answered on Dec 06 2012

    Question

    Customer inquring about IHC-P on human tissue for detecting BMPR2. Also for detecting TRPM8 via ICC and western blot. Customer asked for protocol tips and antibody suggestions.

    Read More

    Abcam community

    Verified customer

    Asked on Nov 28 2012

    Answer

    Thank you for contacting Abcam.

    We spoke earlier about two antibodies:
    anti-BMPR2 ab78422 (https://www.abcam.com/bmpr2-antibody-mm0060-9a10-ab78422.html)
    anti-TRPM8 ab109308 (https://www.abcam.com/trpm8-antibody-epr41962-ab109308.html)

    You mentioned you were interested in testing ab78422 in mouse via IHC-P prior to using the antibody in human samples. Since this would be a mouse on mouse stain, there will be a high level of background due to the mouse antibody binding to native IgG's present in the mouse tissue. Also, our AbTrial program does not apply to mouse on mouse applications. Thus, I highly recommend testing the antibody in your human sections, perhaps sections that are not as crucial to your experiment.

    Additionally, purchase of ab78422 would entitle you to a free rabbit monoclonal antibody through our RabMab promotion. Details of this promotion are given below:
    Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

    Thus, you would be able to receive ab109308, the anti-TRPM8 RabMab that we looked at together earlier with the purchase of ab78422.

    We also have anti-mouse and anti-rabbit secondary antibodies that could be used for ab78422 and ab109308, respectively.
    anti-mouse: https://www.abcam.com/Search?AppliedFacets.FacetProductType=Secondary+antibodies&IsFacetsOnly=False&PageNumber=1&Keywords[0]=anti-mouse&X-Requested-With=XMLHttpRequest
    anti-rabbit:https://www.abcam.com/Search?Keywords=anti-rabbit&fReset=1&pt=7&source=TopSearch&btnSearch=Search

    We also discussed some IHC-P protocol information. I've attached our protocol book which includes IHC-P protocol information as well as other applications. Specifically for ab78422, we discussed attempting a proteinase K enzymatic antigen retrieval. Information regarding a proteinase K antigen retrieval is given below. I also recommend primary antibody dilutions of 1/50, 1/100, and 1/200 to see which dilution gives the best signal to background ratio.
    Proteinase K antigen retrieval information: http://www.ihcworld.com/_protocols/epitope_retrieval/proteinase-k.htm

    We also discussed the western blot bands that you were seeing for TRPM8, with 2 bands appearing (1 at the expected 130 kDa and 1 at 60 kDa). Since the TRPM8 protein is a homotetramer, the 60 kDa band is most likely a homodimer composed of half of the TRPM8 protein. In order to reduce the likelihood of this lower weight band occurring, you can also attempt denaturation in SDS at 70oC for 5-10 minutes rather than boiling at 95-100oC.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Nov 28 2012

    Question

    To whom it may concern,   I’m interested in your products with the references ab6285 and ab78422. I would like to know if you have any information on the cross reactivity of the products with zebrafish samples. If not, would it be possible for you to send me a sample so I can try the antibodies on my samples?   Thank you very much for the attention,   Sincerely,      

    Read More

    Abcam community

    Verified customer

    Asked on Sep 28 2011

    Answer

    Thank you for your enquiry which has been forwarded to the scientific support team. I am sorry to confirm that because we carry over 70,000 products, it is not feasible for us to keep small sample sizes of our products to send to cusotmers. We are happy to reassure our customers that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. With regards to ab6285 Anti-BMP2 antibody [65529.111], I have reviewed the alingment of the immunogen for this antibody to the Zebrafish protein. There is 63% alignment to zebrafish. This alignment is quite low and I would therefore not recommend that this antibody is likely to detect the Zebrafish BMP2. The other antibodies we have to BMP2 are raised against full length human protein or shorter peptides from the human sequence, and they all have the same alignment or less. I am sorry there are no BMP2 antibodies to suggest that may be suitable on this occasion. With regards to BMPR2, the immunogen of ab78422 BMPR2 has only 58% alignment to zebrafish. Again, I am sorry this means it is not likely to crossreact with Zebrafish. However, we do have the following BMPR2 antibody which has 88% alignment to the zebrafish protein. I can recommend to review the online datasheet for further details. BMPR2 antibody (ab106266) https://www.abcam.com/BMPR2-antibody-ab106266.html https://www.abcam.com/BMPR2-antibody-ab106266.html. If you would like to test this antibody in Zebrafish, you may be eligible for our testing discount program if the antibody has not yet been purchased. Please contact our Scientific Support team by replying to this email prior to purchase for more information. Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates. To find out more about our Abreview system, please see the following link: https://www.abcam.com/abreviews I hope this information is helpful. Please do not hesitate to contact me again with any other questions.

    Read More

    Abcam Scientific Support

    Answered on Sep 28 2011

    Question

    I need some help with the antigen retrieval procedure for Immunohistochemistry for paraffine embedded tissue, do you use protease digestion?. What kind, what concentration and for how long do you expose? Also, I would like to know how do you stop efficiently the digestion process by the protease used? What other suggestion do you have? Thank you

    Read More

    Abcam community

    Verified customer

    Asked on Jun 01 2010

    Answer

    Thank you for your inquiry. Please find here the answers to your questions: 1) Proteinase K (20ug/ml) in PBS has been used for antigen retrieval, to pre-treat the tissue section at room temperature for 20-30min 2.) In order to stop the proteinase reaction, cooling down the sections to RT (from 37 degrees) and washing in PBS Tween should be enough. 3.) The primary antibody incubation has been performed at a 1/200 dilution (optimal dilution should be determined by the end user however) overnight at 4 degrees. 4.) Anti mouse HRP polymer system has been used as detection system. 5.) If the signal is too weak, primary ab incubation can be done at room temperature for overnight instead of 4 degree. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Jun 02 2010

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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