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AB24213

Anti-Blood Group H ab antigen 抗体 [97-I]

Anti-Blood Group H ab antigen antibody [97-I]

3

(1 Review)

|

(2 Publications)

Mouse Monoclonal Blood Group H ab antigen antibody. Suitable for IP, Flow Cyt, ELISA, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Blood Group H ab antigen protein.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

97-I

アイソタイプ

IgM

キャリアフリー

No

交差種

Human

アプリケーション

ELISA, WB, Flow Cyt, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

H antigen of red blood cells and body fluids.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.6
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Blood Group H antigen also recognized as the H/AB antigen plays a significant role in determining blood types alongside A and B antigens. This antigen is part of the ABO blood group system where it acts as a precursor to the A and B antigens. The H antigen is expressed at the cell surface of red blood cells. Its molecular mass can vary as it is part of glycoproteins and glycolipids on the cell membrane. The presence and modification of the H antigen will dictate the ABO blood group of an individual serving as a substrate for specific glycosyltransferases that convert it to A or B antigens.
Biological function summary

The H antigen is important in red blood cell recognition and compatibility in transfusion medicine. It serves as a scaffold for the attachment of specific sugars that form A or B antigens. When present as H/AB in its unaltered form it indicates blood group O. The H antigen is not a part of a complex but interplays with enzymes like the A and B transferases that modify it determining individual blood types. Additionally anti-H antibodies can be found in individuals lacking this antigen like in rare Bombay phenotype emphasizing its importance in blood antigenicity.

Pathways

The H antigen's modification by specific glycosyltransferases is pivotal. These glycosylation pathways dictate the conversion of the H antigen to either the A or B antigens utilizing enzymes encoded by the ABO gene. The enzymatic pathways involving the H antigen relate closely with other proteins like FUT1 and FUT2 which are fucosyltransferases adding fucose to form blood group H. These pathways ensure the diverse presentation of antigens important for immune recognition and compatibility during blood transfusion.

The expression of Blood Group H antigen is linked to transfusion reactions and hemolytic disease of the newborn. Individuals with the rare Bombay phenotype lack the H antigen causing them to produce potent anti-H antibodies leading to complications if transfused with regular O A B or AB blood types. Additionally blood antigens including H/AB have implications in infections and pathology such as when pathogens utilize these antigens as receptors. This highlights the interconnectedness of the H antigen with immune response and cellular recognition processes.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Blood Group H ab antigen
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:1765 PubMed36997505

2023

Turning universal O into rare Bombay type blood.

Applications

Unspecified application

Species

Unspecified reactive species

Itxaso Anso,Andreas Naegeli,Javier O Cifuente,Ane Orrantia,Erica Andersson,Olatz Zenarruzabeitia,Alicia Moraleda-Montoya,Mikel García-Alija,Francisco Corzana,Rafael A Del Orbe,Francisco Borrego,Beatriz Trastoy,Jonathan Sjögren,Marcelo E Guerin

BMC research notes 12:607 PubMed31547886

2019

Characterization of human norovirus binding to gut-associated bacterial ligands.

Applications

Unspecified application

Species

Unspecified reactive species

Erin A Almand,Matthew D Moore,Lee-Ann Jaykus
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Product
Primary Antibodies

AB24222

Anti-Blood Group H ab antigen antibody [87-N]

primary-antibodies

blood-group-h-ab-antigen-antibody-87-n-ab24222

4

(1 reviews)

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