Biotin Anti-VDAC1/Porin 抗体 [N152B/23] (ab186262)
Key features and details
- Biotin Mouse monoclonal [N152B/23] to VDAC1/Porin
- Suitable for: WB, ICC/IF
- Reacts with: Rat, Human
- Conjugation: Biotin
- Isotype: IgG2a
Related conjugates and formulations
製品の概要
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製品名
Biotin Anti-VDAC1/Porin antibody [N152B/23]
VDAC1/Porin 一次抗体 製品一覧 -
製品の詳細
Biotin Mouse monoclonal [N152B/23] to VDAC1/Porin -
由来種
Mouse -
標識
Biotin -
特異性
Does not cross-react with VDAC2 or VDAC3 (based on KO validation results).
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アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant full length protein corresponding to Human VDAC1/Porin aa 1 to the C-terminus.
Database link: P21796 -
ポジティブ･コントロール
- WB: Rat brain membrane lysate. ICC/IF: SK-N-BE cells.
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特記事項
The clone number has been updated from S152B-23 to N152B/23, both clone numbers name the same antibody clone.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark. -
バッファー
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
N152B/23 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab186262の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 31 kDa.
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| ICC/IF |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
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WB
Use at an assay dependent concentration. Predicted molecular weight: 31 kDa. |
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ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. -
組織特異性
Heart, liver and skeletal muscle. -
配列類似性
Belongs to the eukaryotic mitochondrial porin family. -
ドメイン
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. -
細胞内局在
Mitochondrion outer membrane. Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 7416 Human
- Entrez Gene: 83529 Rat
- Omim: 604492 Human
- SwissProt: P21796 Human
- SwissProt: Q9Z2L0 Rat
- Unigene: 519320 Human
- Unigene: 709506 Human
- Unigene: 54594 Rat
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別名
- N2441 antibody
- OMP2 antibody
- POR1 antibody
see all
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab186262 は論文での使用が確認できていません。