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AB48350

Biotin Anti-Plasmin 抗体

Biotin Anti-Plasmin antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Plasminogen antibody - conjugated to Biotin. Suitable for ELISA, WB, RIA and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human PLG.

別名を表示する

Plasminogen, PLG

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長
キャリアフリー

No

交差種

Human

アプリケーション

RIA, ELISA, WB

applications

免疫原

Native Full Length Protein corresponding to Human PLG.

P00747

特異性

This antibody does recognize plasminogen at about 20-40 %.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.25% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Plasmin a serine protease enzyme with a mass of approximately 79 kDa is an important player in the fibrinolytic system. Commonly referred to by alternate names like profibrinolysin or fibrinolysin it is mainly expressed in the liver and circulates in the blood as an inactive zymogen called plasminogen. Plasminogen is activated to plasmin through the action of activators such as tissue plasminogen activator (tPA) and urokinase (uPA). The activation to plasmin involves a cleavage at specific peptide bonds which exposes the active site that allows it to function as a protease.
Biological function summary

The enzyme plasmin degrades fibrin in blood clots a critical function in the process of clot resolution. It belongs to the family of serine proteases and does not form part of a larger protein complex. The activity of plasmin is modulated by inhibitors like alpha-2-antiplasmin which bind to plasmin and prevent excessive degradation of fibrin. Bovine plasmin shares similar functions and serves as a model for studying human plasmin activity. Researchers often measure plasmin activity through specific assays to understand changes in fibrinolytic activity within the body.

Pathways

Plasmin plays an integral role in the fibrinolytic pathway and is also involved in tissue remodeling and wound healing. The fibrinolytic pathway centers on the balance of plasminogen activation and inhibition which directly influences thrombolysis. Proteins such as tPA and uPA facilitate the conversion of plasminogen to plasmin and are tightly regulated to ensure proper physiological function. In the context of wound healing plasmin helps activate matrix metalloproteases leading to extracellular matrix breakdown and cell migration.

The regulation of plasmin is closely associated with pathological conditions such as thrombosis and liver disease. An overactive plasmin system can result in conditions like excessive bleeding or hemorrhage while inadequate plasmin activity may lead to thrombosis due to impaired clot breakdown. The interaction between plasmin and plasmin inhibitors like alpha-2-antiplasmin is critical in diseases such as liver cirrhosis where imbalances in fibrinolysis can have significant clinical outcomes. Understanding these interactions helps in developing therapeutic strategies to modulate plasmin activity in various disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed : 6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.. (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed : 21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed : 21949403).. (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue.. (Microbial infection) Interacts with dengue virus type 2 particles (PubMed : 31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed : 31726374).
See full target information PLG
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of cosmetic science 41:624-628 PubMed31604367

2019

Expression and ultrastructural localization of plasmin(ogen) in the terminally differentiated layers of normal human epidermis.

Applications

Unspecified application

Species

Unspecified reactive species

R Voegeli,A V Rawlings,M Haftek

The Journal of biological chemistry 287:22450-62 PubMed22613725

2012

Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells.

Applications

WB

Species

Unspecified reactive species

Vladimir Leksa,Karin Pfisterer,Gabriela Ondrovičová,Brigitte Binder,Silvia Lakatošová,Clemens Donner,Herbert B Schiller,Alexander Zwirzitz,Katarína Mrvová,Vladimir Pevala,Eva Kutejová,Hannes Stockinger

Brain research 1355:7-15 PubMed20709033

2010

Plasminogen and plasmin in Alzheimer's disease.

Applications

WB

Species

Human

Rachel Barker,Seth Love,Patrick G Kehoe

Journal of virology 83:3342-64 PubMed19158252

2009

Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis.

Applications

WB

Species

Human

Sathish Sadagopan,Neelam Sharma-Walia,Mohanan Valiya Veettil,Virginie Bottero,Rita Levine,Richard J Vart,Bala Chandran
View all publications
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組合せ製品

Assay Kits

AB108905

Tissue type Plasminogen Activator Activity Assay Kit (Colorimetric, Human)

Functional Studies - Tissue type Plasminogen Activator Activity Assay Kit (Colorimetric, Human) (AB108905)

  • 5
  • 1
Primary Antibodies

AB259716

Anti-Alpha 2 Antiplasmin antibody [EPR22550-263] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Alpha 2 Antiplasmin antibody [EPR22550-263] - BSA and Azide free (Detector) (AB259716)

  • 0
  • 0
Primary Antibodies

AB315396

Anti-Plasma Kallikrein 1B antibody [RM2034]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [RM2034] (AB315396)

  • 0
  • 0
Primary Antibodies

AB242123

Anti-Factor XII antibody [EPR22292-127]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Factor XII antibody [EPR22292-127] (AB242123)

  • 0
  • 0
Primary Antibodies

AB289971

Anti-HC-II antibody [EPR25618-1]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-HC-II antibody [EPR25618-1] (AB289971)

  • 0
  • 0

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