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AB83435

Biotin Anti-Neuropilin 1 抗体

Biotin Anti-Neuropilin 1 antibody

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(1 Publication)

Anti-Neuropilin 1 antibody conjugated to Biotin is a goat polyclonal antibody suitable for ELISA, Western blot, sELISA, and reacts with human samples.

別名を表示する

CD304, NRP, VEGF165R, NRP1, Neuropilin-1, Vascular endothelial cell growth factor 165 receptor

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長
キャリアフリー

No

交差種

Human

アプリケーション

sELISA, WB, ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human NRP1.

O14786

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代替製品

Primary Antibodies

AB209445

PE Anti-Neuropilin 1 antibody [EPR3113]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - PE Anti-Neuropilin 1 antibody [EPR3113] (AB209445)

  • 0
  • 0
Primary Antibodies

AB197644

Alexa Fluor® 488 Anti-Neuropilin 1 antibody [EPR3113]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Neuropilin 1 antibody [EPR3113] (AB197644)

  • 0
  • 0
Primary Antibodies

AB184783

Anti-Neuropilin 1 antibody [EPR3113] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Neuropilin 1 antibody [EPR3113] - BSA and Azide free (AB184783)

  • 0
  • 0
Primary Antibodies

AB81321

Anti-Neuropilin 1 antibody [EPR3113]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Neuropilin 1 antibody [EPR3113] (AB81321)

  • 4
  • 31
Primary Antibodies

AB25998

Anti-Neuropilin 1 antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Neuropilin 1 antibody (AB25998)

  • 2
  • 1

組合せ製品

Assay Kits

AB227901

Human Neuropilin-1 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Neuropilin-1 ELISA Kit (AB227901)

  • 0
  • 0
Primary Antibodies

AB134101

Anti-IRS2 antibody [EPR904(2)]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRS2 antibody [EPR904(2)] (AB134101)

  • 0
  • 0
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
Proteins & Peptides

AB132179

Recombinant Human Neuropilin 1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Neuropilin 1 protein (GST tag N-Terminus) (AB132179)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human Neuropilin 1.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>The detection limit for recombinant human Neuropilin 1 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>When used as detection antibody paired with recommended antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant human Neuropilin 1.</p>" } } }
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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
Reconstitute in PBS, 0.1% BSA
精製度
IgG fraction
精製に関する特記事項
ab83435 is sterile filtered.This antibody was purified by affinity chromatography and then biotinylated.
バッファー組成
pH: 7.2 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Neuropilin-1 also known as NRP1 is a transmembrane protein with a significant role in the nervous and vascular systems. It has a molecular mass of approximately 130 kDa. Neuropilin-1 expression occurs broadly in tissues including neurons endothelial cells and tumor cells. Its structure includes a large extracellular domain that binds various ligands mediating several cellular functions. Neuropilin-1 is sometimes targeted in experiments using methods like neuropilin-1 ELISA and PE immunofluorescence to study its distribution and function in different tissues.
Biological function summary

Neuropilin-1 serves as a co-receptor for both the Vascular Endothelial Growth Factor (VEGF) and Semaphorin family proteins. It plays an important role in processes such as angiogenesis axonal guidance and the immune system. Neuropilin-1 does not function alone; it forms complexes with neuropilin-2 and other receptors like Plexin and VEGFR enhancing signal transduction pathways for angiogenesis and neuronal development. This involvement allows cells to respond appropriately to their environment especially during organismal development and repair processes.

Pathways

Neuropilin-1 facilitates interactions within the VEGF and Semaphorin pathways. In the VEGF pathway Neuropilin-1 enhances binding and signaling efficiency with VEGF closely working alongside VEGFR to promote endothelial cell survival migration and new blood vessel formation. In the Semaphorin pathway Neuropilin-1 interacts with Plexins mediating neuronal pathfinding and axonal growth. These interactions highlight Neuropilin-1's adaptive capabilities in various physiological processes critical for system development.

Neuropilin-1 is linked to pathological conditions like cancer and cardiovascular diseases. Neuropilin-1 overexpression is frequently observed in tumors driving cancer progression through enhanced angiogenesis and tissue invasion closely interacting with proteins like VEGF-A. In cardiovascular disease Neuropilin-1 contributes to abnormal blood vessel formation and stability. By studying Neuropilin-1 and other biomarkers like CD304 FITC researchers aim to develop therapeutic strategies targeting its role in these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed : 10688880, PubMed : 9288753, PubMed : 9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed : 19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed : 10688880, PubMed : 19805273, PubMed : 9288753, PubMed : 9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed : 30623799).. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.. Isoform 2. Binds VEGF-165 and may inhibit its binding to cells (PubMed : 10748121, PubMed : 26503042). May induce apoptosis by sequestering VEGF-165 (PubMed : 10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
See full target information NRP1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 31:107802 PubMed32579928

2020

Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.

Applications

Unspecified application

Species

Unspecified reactive species

Tamihiro Kamata,Tsz Y So,Qasim Ahmed,Susan Giblett,Bipin Patel,Jinli Luo,Roger Reddel,Catrin Pritchard
View all publications
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