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AB20027

Biotin Anti-Mycobacterium tuberculosis 抗体

Biotin Anti-Mycobacterium tuberculosis antibody

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(1 Publication)

Rabbit Polyclonal Mycobacterium tuberculosis antibody - conjugated to Biotin. Suitable for IHC-P and reacts with Mycobacterium tuberculosis samples. Cited in 1 publication.

別名を表示する

M. tuberculosis

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長
キャリアフリー

No

交差種

Mycobacterium tuberculosis

アプリケーション

IHC-P

applications

特異性

Minimum of two major M. tuberculosis bands by immunoelectrophoresis (gamma & beta).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mycobacterium tuberculosis": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
IgG fraction covalently coupled with the N-Hydroxysuccinimide ester of biotin under mild conditions to give a high degree of substitution.
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Mycobacterium tuberculosis sometimes referred to as M. tuberculosis is a pathogenic bacterial species in the Mycobacterium genus. It is the causative agent of tuberculosis (TB) in humans and has a relatively large cellular mass characterized by a thick and complex cell wall rich in mycolic acids. This bacterium expresses in the lungs where it primarily resides in pulmonary macrophages after inhalation. The robust cell wall serves as a barrier against phagocytosis and contributes to its resistance to many antimicrobial agents.
Biological function summary

The bacteria stimulate a host immune response causing the formation of granulomas which are small nodular aggregations of immune cells. Mycobacterium tuberculosis employs several mechanisms to inhibit the lysosomal degradation processes in macrophages. It is part of a complex interplay involving the immune system which tries to control its spread. This interaction allows it to persist in a dormant state within the host making it difficult to eradicate completely and able to reactivate later.

Pathways

Mycobacterium tuberculosis's survival and pathogenicity involve several critical biological processes. The bacteria actively dodge destruction through pathways that inhibit host cell apoptosis and modulate cytokine production. Specific proteins like the 6-kda early secretory antigen target (ESAT-6) and culture filtrate protein 10 (CFP-10) complexes play a vital role in these mechanisms manipulating host immune signaling pathways to facilitate prolonged infection.

Mycobacterium tuberculosis is directly associated with tuberculosis a disease that can affect different body organs but most often targets the lungs. The pathogen’s persistence mechanisms implicate it in chronic infections and proteins like Ag85 complex interact with host defenses to further complicate control of the disease. Another disorder linked to its infection is latent TB where the bacteria remain inactive but viable within the host posing ongoing public health challenges.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Mycobacterium tuberculosis
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Veterinary pathology 50:343-6 PubMed22711744

2012

Probable Blastomyces dermatitidis infection in a young rat.

Applications

Unspecified application

Species

Unspecified reactive species

S C Chang,S L Hsuan,C C Lin,W C Lee,M S Chien,L C Chen,J H Wu,S J Cheng,C L Chen,J W Liao
View all publications
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代替製品

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組合せ製品

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