Biotin Anti-Granzyme B 抗体 [GZMB/3014]
Biotin Anti-Granzyme B antibody [GZMB/3014]
Be the first to review this product! Submit a review
|
(1 Publication)
Anti-Granzyme B antibody [GZMB/3014] conjugated to Biotin - suitable for IHC-P, Protein Array, and reacts with human samples. Clone [GZMB/3014] is a mouse monoclonal antibody.
別名を表示する
CGL1, CSPB, CTLA1, GRB, GZMB, Granzyme B, C11, CTLA-1, Cathepsin G-like 1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, Granzyme-2, Human lymphocyte protein, SECT, T-cell serine protease 1-3E, CTSGL1, Lymphocyte protease, HLP
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Granzyme B antibody [GZMB/3014] (AB271818)
Formalin-fixed, paraffin-embedded human spleen tissue stained for Granzyme B using Biotinylated ab271818 at 4 μg/ml in
immunohistochemical analysis
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Granzyme B antibody [GZMB/3014] (AB271818)
Formalin-fixed, paraffin-embedded human spleen tissue stained for Granzyme B using Biotinylated ab271818 at 4 μg/ml in immunohistochemical analysis
- Protein Array
Unknown
Protein Array - Biotin Anti-Granzyme B antibody [GZMB/3014] (AB271818)
Analysis of Protein Array containing >19,000 full-length human proteins using Granzyme B ab271818. Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
出荷温度及び保存条件
製品の状態
精製方法
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Granzyme B participates prominently in the immune response by activating caspases particularly caspase-3 which promotes the breakdown of cellular components necessary for apoptosis. Granzyme B does not function in isolation but acts in concert with other immune system factors such as perforin to effectively induce cell death. Perforin creates pores in the target cell membrane allowing granzyme B to enter and instigate the apoptosis sequence. The enzyme also contributes to the processing of cytokines which enhances the immune response further.
Pathways
Studies have determined that granzyme B is critical in the apoptosis pathway particularly in the granule exocytosis pathway. It closely interacts with proteins such as perforin and other granzymes to mediate apoptosis in target cells. Granzyme B also plays a role in the inflammatory response and can influence pathways associated with cytotoxic T cell signaling. Its pathway interactions ensure effective elimination of damaged or infected cells maintaining tissue homeostasis.
製品プロトコール
- Visit the General protocols
- Visit the Troubleshooting
ターゲットの情報
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
Journal of immunology research 2022:3351268 PubMed35571569
2022
Applications
Unspecified application
Species
Unspecified reactive species
Abcam product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com