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AB84261

Biotin Anti-Flt3 ligand/Flt3L 抗体

Biotin Anti-Flt3 ligand/Flt3L antibody

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(1 Publication)

Rabbit Polyclonal Flt3 ligand/Flt3L antibody - conjugated to Biotin. Carrier free. Suitable for sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FLT3LG.

別名を表示する

Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine, FLT3LG

1 Images
Sandwich ELISA - Biotin Anti-Flt3 ligand/Flt3L antibody (AB84261)
  • sELISA

Supplier Data

Sandwich ELISA - Biotin Anti-Flt3 ligand/Flt3L antibody (AB84261)

To detect human Flt3 ligand/Flt3L by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.25 – 1.0 μg/ml of ab84261 is required. This biotinylated polyclonal antibody, in conjunction with an anti-Flt3 ligand/Flt3L (ab9688) as a capture antibody, allows the detection of at least 0.2 – 0.4 ng/well of recombinant human Flt3 ligand/Flt3L.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長
キャリアフリー

Yes

交差種

Human

アプリケーション

sELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human FLT3LG.

P49771

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.25-1 µg/mL", "sELISA-species-notes": "<p>Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human Flt3 ligand.</p>" } } }
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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
Reconstitute in PBS, 0.1% BSA
精製方法
Affinity purification Protein A
精製に関する特記事項
ab84261 is sterile filtered.
バッファー組成
Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Flt3 ligand (Flt3L) also known as Flt3-L Flt3 ligand protein or flt-3 ligand protein is a small cytokine with a molecular mass of approximately 18 to 19 kDa. It acts as a growth factor by binding to the Flt3 receptor tyrosine kinase on the surface of hematopoietic progenitor cells. Flt3L is expressed in various tissues including the bone marrow where it plays a significant role in hematopoiesis. It is critical in dendritic cell and B cell development impacting the immune response mechanism.
Biological function summary

The Flt3 ligand plays an essential role in the immune system. It is a monomeric cytokine that induces proliferation of early lineage cells within the hematopoietic system. Flt3L does not function as part of a complex but acts independently to stimulate the proliferation differentiation and survival of hematopoietic cells. By interacting directly with its receptor it significantly influences the innate and adaptive immune systems through the maturation of dendritic and B cells.

Pathways

The Flt3 ligand is involved in hematopoietic signaling pathways primarily the PI3K-Akt signaling pathway. This pathway is essential for cell survival and growth where Flt3L aids in transmitting growth signals necessary for hematopoietic cells. Flt3L also interacts with proteins such as FLT3 receptor and influences the downstream signaling cascade affecting cell fate decisions in hematopoiesis and immune cell maturation.

Flt3 ligand is connected to leukemia particularly acute myeloid leukemia (AML) due to dysregulation of the FLT3 signaling pathway. Mutations in the FLT3 receptor can lead to uncontrolled cell proliferation contributing to tumorigenesis. Additionally Flt3L plays a role in autoimmune disorders by influencing immune cell development. It is closely connected with the FLT3 receptor and other tyrosine kinases which when mutated can exacerbate disease pathology through abnormal cell signaling and proliferation.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs).
See full target information FLT3LG
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

ACS applied materials & interfaces 15:25300-25312 PubMed37204867

2023

Toehold-Mediated Shape Transition of Nucleic Acid Nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Jordan Hartung,Nathan McCann,Erwin Doe,Hannah Hayth,Kheiria Benkato,M Brittany Johnson,Mathias Viard,Kirill A Afonin,Emil F Khisamutdinov
View all publications
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代替製品

Primary Antibodies

AB9688

Anti-Flt3 ligand/Flt3L antibody

Sandwich ELISA - Anti-Flt3 ligand/Flt3L antibody (AB9688)

  • 0
  • 0
Primary Antibodies

AB231249

Anti-Flt3 ligand/Flt3L antibody

Western blot - Anti-Flt3 ligand/Flt3L antibody (AB231249)

  • 0
  • 0
Primary Antibodies

AB238610

Anti-Flt3 ligand/Flt3L antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Flt3 ligand/Flt3L antibody (AB238610)

  • 0
  • 0
Primary Antibodies

AB231192

Anti-Flt3 ligand/Flt3L antibody

Western blot - Anti-Flt3 ligand/Flt3L antibody (AB231192)

  • 0
  • 0
Primary Antibodies

AB52648

Anti-Flt3 ligand/Flt3L antibody [EP1140Y]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Flt3 ligand/Flt3L antibody [EP1140Y] (AB52648)

  • 4
  • 3
Primary Antibodies

AB232487

Anti-Flt3 ligand/Flt3L antibody [EP1140Y] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Flt3 ligand/Flt3L antibody [EP1140Y] - BSA and Azide free (AB232487)

  • 0
  • 0

組合せ製品

Assay Kits

AB254507

Human Flt-3 ligand ELISA Kit

Recombinant|SimpleStep

ELISA - Human Flt-3 ligand ELISA Kit (AB254507)

  • 0
  • 0
Proteins & Peptides

AB270071

Recombinant mouse Flt3 ligand/Flt3L protein (Active)

Premium Bioactive

Functional Studies - Recombinant mouse Flt3 ligand/Flt3L protein (Active) (AB270071)

  • 0
  • 0
Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
  • 6
Assay Kits

AB254507

Human Flt-3 ligand ELISA Kit

Recombinant|SimpleStep

ELISA - Human Flt-3 ligand ELISA Kit (AB254507)

  • 0
  • 0
Proteins & Peptides

AB310789

Recombinant Human DLL4 Protein (His Tag)

SDS-PAGE - Recombinant Human DLL4 Protein (His Tag) (AB310789)

  • 0
  • 0

Abcam product promise

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