Biotin Anti-CD42b 抗体 [AK2] (ab30400)
![Flow Cytometry - Biotin Anti-CD42b antibody [AK2] (ab30400)](https://www.abcam.co.jp/ps/products/30/ab30400/Images/ab30400-40382-anti-cd42b-antibody-ak2-biotin-flow-cytometry.jpg "Flow Cytometry - Biotin Anti-CD42b antibody [AK2] (ab30400)")
Key features and details
- Biotin Mouse monoclonal [AK2] to CD42b
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
製品の概要
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製品名
Biotin Anti-CD42b antibody [AK2]
CD42b 一次抗体 製品一覧 -
製品の詳細
Biotin Mouse monoclonal [AK2] to CD42b -
由来種
Mouse -
標識
Biotin -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
The details of the immunogen for this antibody are not available.
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ポジティブ･コントロール
- Human peripheral blood platelets
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特記事項
Clone AK2 has been reported to block the binding of von Willebrand Factor to platelets.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
精製度
Protein G purified -
一次抗体 備考
Clone AK2 has been reported to block the binding of von Willebrand Factor to platelets. -
ポリ/モノ
モノクローナル -
クローン名
AK2 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab30400の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
Use neat or 10µl for 100µl of whole blood.
ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
|
| 特記事項 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. Use neat or 10µl for 100µl of whole blood.
ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
|
ターゲット情報
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機能
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. -
関連疾患
Non-arteritic anterior ischemic optic neuropathy
Bernard-Soulier syndrome
Bernard-Soulier syndrome A2, autosomal dominant
Pseudo-von Willebrand disease -
配列類似性
Contains 7 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
翻訳後修飾
Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2811 Human
- Omim: 606672 Human
- SwissProt: P07359 Human
- Unigene: 1472 Human
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別名
- Antigen CD42b alpha antibody
- Antigen CD42b-alpha antibody
- BDPLT1 antibody
see all
画像
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Flow Cytometry - Biotin Anti-CD42b antibody [AK2] (ab30400)Flow cytometric analysis of CD42b expressing cells in human periferal blood platelets using ab30400.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab30400 は 2 報の論文で使用されています。
- Montoro-García S et al. Small-size platelet microparticles trigger platelet and monocyte functionality and modulate thrombogenesis via P-selectin. Br J Haematol 166:571-80 (2014). PubMed: 24766273
- Kumar RA et al. Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates. Biophys J 85:4099-109 (2003). PubMed: 14645097
