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AB95688

Biotin Anti-CD105 抗体 [MJ7/18]

Biotin Anti-CD105 antibody [MJ7/18]

3

(1 Review)

|

(1 Publication)

Anti-CD105 antibody [MJ7/18] conjugated to Biotin - suitable for flow cytometry, and reacts with mouse samples. Clone [MJ7/18] is a rat monoclonal antibody and one of the most commonly used clones for flow cytometry.

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別名を表示する

CD105, Edg, Eng, Endoglin, Cell surface MJ7/18 antigen

1 Images
Flow Cytometry - Biotin Anti-CD105 antibody [MJ7/18] (AB95688)
  • Flow Cyt

Unknown

Flow Cytometry - Biotin Anti-CD105 antibody [MJ7/18] (AB95688)

Surface staining of bEND.3 cell line with 0.25 µg of ab95688 followed by Streptavidin PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

MJ7/18

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

標識

Biotin

励起波長/蛍光波長
キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt

applications

免疫原

Tissue preparation containing Eng protein. The exact immunogen used to generate this antibody is proprietary information.

Q63961

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代替製品

Primary Antibodies

AB11414

Anti-CD105 antibody [SN6]

Flow Cytometry - Anti-CD105 antibody [SN6] (AB11414)

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Primary Antibodies

AB206419

Anti-CD105 antibody [EPR19911]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR19911] (AB206419)

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  • 0
Primary Antibodies

AB170943

Anti-CD105 antibody [EPR10145-10]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR10145-10] (AB170943)

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  • 0
Primary Antibodies

AB169545

Anti-CD105 antibody [EPR10145-12]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR10145-12] (AB169545)

  • 4
  • 3
Primary Antibodies

AB219362

Anti-CD105 antibody [EPR10145-12] - Low endotoxin, Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR10145-12] - Low endotoxin, Azide free (AB219362)

  • 5
  • 1
Primary Antibodies

AB221675

Anti-CD105 antibody [EPR21846]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR21846] (AB221675)

  • 0
  • 0
Primary Antibodies

AB231832

Anti-CD105 antibody [EPR21846] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD105 antibody [EPR21846] - BSA and Azide free (AB231832)

  • 0
  • 0

組合せ製品

Assay Kits

AB217773

Human CD105 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CD105 ELISA Kit (AB217773)

  • 0
  • 0
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

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Primary Antibodies

AB303477

Alexa Fluor® 647 Anti-Ly-6A/E (Sca-1) antibody [EPR22502-38]

RabMAb|Recombinant|Trial Size

Flow Cytometry - Alexa Fluor® 647 Anti-Ly-6A/E (Sca-1) antibody [EPR22502-38] (AB303477)

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  • 0
Primary Antibodies

AB306534

Alexa Fluor® 647 Anti-c-Kit antibody [EPR24708-25]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-c-Kit antibody [EPR24708-25] (AB306534)

  • 0
  • 0
Primary Antibodies

AB315961

Alexa Fluor® 488 Anti-CD90 / Thy1 antibody [EPR28145-53]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD90 / Thy1 antibody [EPR28145-53] (AB315961)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p>Use a final volume of 100μl.</p><p><a href='/products/primary-antibodies/biotin-rat-igg2a-kappa-monoclonal-rtk2758-isotype-control-ab18445'>ab18445</a> - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.
Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed : 10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed : 28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
See full target information Eng
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Virus research 222:64-70 PubMed27264433

2016

Select membrane proteins modulate MNV-1 infection of macrophages and dendritic cells in a cell type-specific manner.

Applications

Unspecified application

Species

Unspecified reactive species

Juliana Bragazzi Cunha,Christiane E Wobus
View all publications
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