AB47864

Biotin Anti-Bradykinin 抗体

Name: Biotin Anti-Bradykinin 抗体 (ab47864) | Abcam
Brand: Abcam Limited
SKU: AB47864
Price: 76000 JPY
Availability: InStock

Biotin Anti-Bradykinin antibody

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(2 Publications)

Rabbit Polyclonal Kininogen antibody - conjugated to Biotin. Suitable for IP, ELISA, RIA and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human KNG1 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

BDK, KNG, KNG1, Kininogen-1, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, HMWK

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長

キャリアフリー

交差種

Human

アプリケーション

RIA, IP, ELISA

applications

免疫原

Synthetic Peptide within Human KNG1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P01042

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.5 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 50% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Bradykinin also known as bradykinin (BK) is a peptide that plays an important role in multiple physiological processes. Bradykinin consists of nine amino acids and typically has a molecular weight of around 1060 daltons. It is primarily expressed in endothelial cells and can be produced by blood plasma proteins in response to specific stimuli. Bradykinin exemplifies a mediator of inflammation and vasodilation contributing significantly to vascular permeability and lowering blood pressure.

Biological function summary

This peptide acts as an important modulator in inflammatory and pain processes. It forms part of the kallikrein-kinin system where it interacts with specific G-protein-coupled receptors known as bradykinin receptor B1 and B2. Bradykinin contributes to complex biological functions including the dilation of blood vessels smooth muscle contraction and activation of pain fiber nerve endings. This activity makes it critical for the body’s response to inflammation and injury.

Pathways

Bradykinin participates in the kallikrein-kinin system and the renin-angiotensin system. In the renin-angiotensin system bradykinin is related to angiotensin-converting enzyme (ACE) which degrades bradykinin and counters its vasodilatory effects. Bradykinin's role in inflammation and blood pressure regulation is linked closely to other vasoactive peptides and cytokines contributing to its importance in diverse physiological pathways.

Bradykinin is associated with conditions such as hereditary angioedema and chronic cough. In hereditary angioedema excessive bradykinin production leads to recurrent episodes of swelling due to its capacity to increase vascular permeability. The peptide also plays a role in inducing a chronic cough as an adverse reaction via its action on sensory neurons in the respiratory tract. This is often observed in patients using ACE inhibitors as the inhibition leads to increased levels of bradykinin.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.. Bradykinin. The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects : (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).

See full target information KNG1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Open veterinary journal 13:150-170 PubMed37073241

2023

Long-term histological effects of high-dose prednisolone administration on the mitral valve in normal Beagle dogs.

Applications

Unspecified application

Species

Unspecified reactive species

Sachiyo Tanaka,Shuji Suzuki,Misaki Shimura,Asaka Kawana,Aki Tanaka,Satoshi Soeta,Yasushi Hara

Advances in clinical and experimental medicine : official organ Wroclaw Medical University 30:623-632 PubMed34018345

2021

Investigation of the role of miR-221 in diabetic peripheral neuropathy and related molecular mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wu,Xiaoyu Wang,Yiyu Yin,Lei Zhu,Fengchao Zhang,Jianping Yang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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Biotin Anti-Bradykinin 抗体

Biotin Anti-Bradykinin antibody

Key facts

宿主種

クローン性

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Assay Kits

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise