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AB27636

Biotin Anti-Apolipoprotein A II/ApoA-II 抗体

Biotin Anti-Apolipoprotein A II/ApoA-II antibody

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Sheep Polyclonal Apolipoprotein A II/ApoA-II antibody. Suitable for ELISA, WB and reacts with Human samples.

別名を表示する

Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2, APOA2

Key facts

宿主種

Sheep

クローン性

Polyclonal

アイソタイプ

IgG

標識

Biotin

励起波長/蛍光波長
キャリアフリー

No

交差種

Human

アプリケーション

WB, ELISA

applications

免疫原

Native Full Length Protein corresponding to Human APOA2.

P02652

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
Purified by human Apolipoprotein A II/ApoA-II-Sepharose™ affinity column.
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.02% Sodium azide Constituents: 0.435% Sodium chloride, 0.2% PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein A-II (also known as ApoA-II or Apolipoprotein A2) is a pivotal protein component of high-density lipoproteins (HDL) in the plasma. It is encoded by the APOA2 gene in humans and displays a molecular mass of approximately 17.4 kDa. Apolipoprotein A-II is primarily expressed in the liver and secreted into the bloodstream where it plays a direct role in lipid metabolism. Its structural composition includes a highly amphipathic α-helical structure that facilitates interaction with lipids aiding in lipoprotein formation and stability.
Biological function summary

Apolipoprotein A-II serves as a significant regulator of HDL metabolism and lipid transport. It is an integral part of HDL particles contributing to their stability and function. Apolipoprotein A-II influences lecithin-cholesterol acyltransferase (LCAT) activity which affects cholesterol esterification. Although less studied than its counterpart Apolipoprotein A-I ApoA-II's interaction with lipids and proteins such as CETP (cholesteryl ester transfer protein) suggests its involvement in lipid exchange and reverse cholesterol transport processes.

Pathways

Apolipoprotein A-II impacts the reverse cholesterol transport pathway and lipid metabolic processes. ApoA-II works closely with its relative Apolipoprotein A-I both part of the same HDL complex. Together they play essential roles in maintaining cholesterol homeostasis and promoting cholesterol efflux from cells back to the liver. The mechanism by which it modulates the function of lipoprotein lipase and hepatic lipase further implicates its role in lipid metabolism and energy balance processes.

Dysfunction or abnormal levels of Apolipoprotein A-II have associations with cardiovascular diseases and metabolic syndromes. Altered ApoA-II levels correlate with an increased risk of atherosclerosis as its imbalance can drive perturbations in HDL composition and function. Moreover research links Apolipoprotein A-II with insulin resistance linking it with ApoA-I imbalanced lipid transport and metabolism in obesity and diabetes contexts. Understanding these connections may guide therapeutic strategies targeting ApoA-II to mitigate the risks and progression of these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
See full target information APOA2
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代替製品

Primary Antibodies

AB92478

Anti-Apolipoprotein A II/ApoA-II antibody [EPR2913]

  • 5
  • 1
Primary Antibodies

AB119990

Anti-Apolipoprotein A II/ApoA-II antibody [EP2912]

  • 0
  • 0
Primary Antibodies

AB238915

Anti-Apolipoprotein A II/ApoA-II antibody [EP2912] - BSA and Azide free

  • 0
  • 0

組合せ製品

Primary Antibodies

AB125084

Anti-C14orf133 antibody

  • 0
  • 0
Assay Kits

AB184859

Human Apolipoprotein AII ELISA Kit

  • 5
  • 1
Primary Antibodies

AB166610

Anti-alpha 1 Antitrypsin antibody [EPR9090]

  • 3
  • 1
Primary Antibodies

AB315287

Anti-AAV2 Capsid protein VP1 antibody [EPR28595-59]

  • 0
  • 0

Abcam product promise

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