Anti-BFL-1/GRS 抗体 (ab45413)
Key features and details
- Rabbit polyclonal to BFL-1/GRS
- Suitable for: IHC-P, WB, ICC
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-BFL-1/GRS antibody
BFL-1/GRS 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to BFL-1/GRS -
由来種
Rabbit -
特異性
This antibody is specific for Bcl2A1 / GRS.
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アプリケーション
適用あり: IHC-P, WB, ICCmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human BFL-1/GRS (C terminal).
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ポジティブ･コントロール
- WB: Human lung and kidney tissue. IHC: Mouse kidney tissue. ICC: Mouse kidney cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab45413の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
Use a concentration of 10 - 20 µg/ml.
IHC-P suitable for Mouse samples only |
|
| WB |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 20 kDa.
WB suitable for Human samples only |
|
| ICC |
Use a concentration of 20 µg/ml.
ICC suitable for Mouse samples only |
| 特記事項 |
|---|
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IHC-P
Use a concentration of 10 - 20 µg/ml. IHC-P suitable for Mouse samples only |
|
WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 20 kDa. WB suitable for Human samples only |
|
ICC
Use a concentration of 20 µg/ml. ICC suitable for Mouse samples only |
ターゲット情報
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機能
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. -
組織特異性
Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. -
配列類似性
Belongs to the Bcl-2 family. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 597 Human
- Entrez Gene: 12044 Mouse
- Omim: 601056 Human
- SwissProt: Q16548 Human
- SwissProt: Q07440 Mouse
- Unigene: 227817 Human
- Unigene: 425593 Mouse
- Unigene: 479217 Mouse
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別名
- ACC 1 antibody
- ACC 2 antibody
- B2LA1_HUMAN antibody
see all
画像
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Western blot - Anti-BFL-1/GRS antibody (ab45413)All lanes : Anti-BFL-1/GRS antibody (ab45413) at 1 µg/ml
Lane 1 : Human kidney tissue lysate
Lane 2 : Human lung tissue lysate
Predicted band size: 20 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BFL-1/GRS antibody (ab45413)ab45413 at 10µg/ml staining BFL-1/GRS in mouse kidney tissue by IHC
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Immunocytochemistry - Anti-BFL-1/GRS antibody (ab45413)Immunocytochemistry of BFL-1/GRS in Mouse Kidney cells using ab45413 at 20 ug/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab45413 は 10 報の論文で使用されています。
- Zhu F et al. Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax. Haematologica 109:186-199 (2024). PubMed: 37534528
- Kohli J et al. Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Nat Commun 13:7923 (2022). PubMed: 36564381
- Marques-Piubelli ML et al. Expression of BCL2 alternative proteins and association with outcome in CLL patients treated with venetoclax. Leuk Lymphoma 62:1129-1135 (2021). PubMed: 33327833
- Hao Y et al. Transcriptomic Signatures and Functional Network Analysis of Chronic Rhinosinusitis With Nasal Polyps. Front Genet 12:609754 (2021). PubMed: 33603773
- He M et al. MicroRNA-664a-3p inhibits the proliferation of ovarian granulosa cells in polycystic ovary syndrome and promotes apoptosis by targeting BCL2A1. Ann Transl Med 9:852 (2021). PubMed: 34164486
- Liang R et al. The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers (Basel) 13:N/A (2021). PubMed: 34572804
- Wu CT et al. MicroRNA-326 aggravates acute lung injury in septic shock by mediating the NF-?B signaling pathway. Int J Biochem Cell Biol 101:1-11 (2018). IHC-P, WB ; Mouse . PubMed: 29727715
- Lu W et al. Fordin: A novel type I ribosome inactivating protein from Vernicia fordii modulates multiple signaling cascades leading to anti-invasive and pro-apoptotic effects in cancer cells in vitro. Int J Oncol 53:1027-1042 (2018). PubMed: 30015835
- Jauharoh SN et al. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production. Biochem Biophys Res Commun 417:582-7 (2012). WB ; Human . PubMed: 22178074
- Fardin P et al. Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice. PLoS One 4:e7058 (2009). IHC-P ; Mouse . PubMed: 19759912