AB151713

Anti-beta Crystallin A3 抗体 [EPR9585]

Anti-beta Crystallin A3 antibody [EPR9585]

RabMAb
Recombinant
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(1 Publication)

Rabbit Recombinant Monoclonal beta Crystallin A3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication.

別名を表示する

CRYB1, CRYBA1, Beta-crystallin A3

1 Images

Unknown

Western blot - Anti-beta Crystallin A3 antibody [EPR9585] (AB151713)

All lanes:

Western blot - Anti-beta Crystallin A3 antibody [EPR9585] (ab151713) at 1/1000 dilution

Lane 1:

Mouse eyeball lysate at 10 µg

Lane 2:

Rat eyeball lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 25 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR9585

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Conditional Ambient

短期保存温度

+4°C

長期保存温度

-20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Beta Crystallin A3 also known as CRYBA3 is a protein involved in the structural formation of the vertebrate eye lens. This protein belongs to the beta/gamma crystallin family characterized by double Greek key motifs. Beta Crystallin A3 has a molecular mass of approximately 24 kDa. It is synthesized in the lens fibers where it plays a role in maintaining transparency and refractive properties essential for vision. Other tissues may express it at much lower levels indicating its specific function in the lens.

Biological function summary

The protein plays a critical role in the formation of the lens's refractive index. It is not part of a complex but exists as a monomer unlike some other crystallins that form oligomers. Its function is to contribute to the lens's structural stability and its ability to focus light. The consistent production and maintenance of this protein are necessary to ensure the lens’s optical clarity over time which is vital for proper vision.

Pathways

Beta crystallin A3 interplays with stabilization pathways related to protein folding within the lens. It is connected to the cytoskeletal pathway which helps maintain the lens's shape and structure. Proteins such as alpha crystallins acting as chaperones interact with beta crystallins to prevent aggregation and maintain solubility in the dense environment of the lens.

Mutations in beta crystallin A3 associate with cataract formation in humans which leads to lens opacities and vision impairment. Cataracts are often linked with disruptions in protein folding and solubility. In this context the protein’s relationship with alpha crystallin is significant because alpha crystallin's chaperone activity can mitigate aggregation issues that lead to cataracts. Understanding these protein interactions helps develop therapeutic strategies to prevent or treat lens opacity.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Crystallins are the dominant structural components of the vertebrate eye lens.

See full target information CRYBA1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 16:915969 PubMed35669106

2022

Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Du,Chang-Hong Li,Ruo-Bing Gao,Xiao-Qing Cen,Ping Li

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-beta Crystallin A3 抗体 [EPR9585]

Anti-beta Crystallin A3 antibody [EPR9585]

Western blot - Anti-beta Crystallin A3 antibody [EPR9585] (AB151713)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

Abcam product promise